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Titolo:
Baseline CD4(+) cell count, not viral load, correlates with virologic suppression induced by potent antiretroviral therapy
Autore:
Skowron, G; Street, JC; Obee, EM;
Indirizzi:
Boston Univ, Roger Williams Med Ctr, Providence, RI 02908 USA Boston UnivProvidence RI USA 02908 ams Med Ctr, Providence, RI 02908 USA SandlerSci, New York, NY USA SandlerSci New York NY USASandlerSci, New York, NY USA IBM Global Serv, New York, NY USA IBM Global Serv New York NY USAIBM Global Serv, New York, NY USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 4, volume: 28, anno: 2001,
pagine: 313 - 319
SICI:
1525-4135(200112)28:4<313:BCCCNV>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND TRIAL; HIV-1 INFECTION; COMBINATION; INDINAVIR; NEVIRAPINE; ZIDOVUDINE; LAMIVUDINE; RNA; LYMPHOCYTES; DIDANOSINE;
Keywords:
nevirapine; efavirenz; indinavir; nelfinavir; viral load; CD4(+) cell count; initial therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Skowron, G Boston Univ, Roger Williams Med Ctr, 825 Chalkstone Ave, Providence, RI 02908 USA Boston Univ 825 Chalkstone Ave Providence RI USA 02908 2908 USA
Citazione:
G. Skowron et al., "Baseline CD4(+) cell count, not viral load, correlates with virologic suppression induced by potent antiretroviral therapy", J ACQ IMM D, 28(4), 2001, pp. 313-319

Abstract

Objective: To investigate the relationship between viral load suppression and baseline viral load as well as that between viral load suppression and baseline CD4(+) cell count. Design: Meta-analysis of published and presented studies. Methods: Trials of two nucleoside analogs plus nevirapine, indinavir, nelfinavir, or efavirenz as therapy for antiretroviral treatment-naive patientswith HIV infection or AIDS who were followed-up for at least 6 months wereincluded in the meta-analysis. The proportion of patients with viral loadsof < 200-500 copies/ml at 6 and 12 months (total number of patients, 1619 and 761, respectively) was regressed to the mean or median baseline viral load and CD4(+) cell count. Results: Thirty-six treatment arms from 30 studies were identified. Multivariate regression demonstrated a significant correlation between baseline CD4(+) cell count and virologic suppression at 6 and 12 months (t = 2.85, p = .008 and t = 3.08, p = .010, respectively) but not between baseline viralload and virologic suppression (t = 0.92, p = .365 and t = 1.31, p = .215,respectively). The same pattern was seen in a subanalysis of trials of nevirapine-containing therapy (CD4(+) cell count: t = 2.89, p = .014 at 6 months; viral load suppression: t = 0.84, p = .415). Conclusions: Baseline CD4(+) cell count was a better predictor of virologic suppression induced by triple combination therapy than was baseline viralload.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:37:47