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Titolo:
Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT-14 by IFN gamma and up-regulation of WNT14B by beta-estradiol
Autore:
Kirikoshi, H; Sekihara, H; Katoh, M;
Indirizzi:
Natl Canc Ctr, Res Inst, Genet & Cell Biol Sect, Div Genet,Chuo Ku, Tokyo 1040045, Japan Natl Canc Ctr Tokyo Japan 1040045 iv Genet,Chuo Ku, Tokyo 1040045, Japan Yokohama City Univ, Sch Med, Dept Internal Med 3, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 6, volume: 19, anno: 2001,
pagine: 1221 - 1225
SICI:
1019-6439(200112)19:6<1221:EOWAWM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-CLONING; CELL-LINE; CHROMOSOMAL LOCALIZATION; GENOMIC STRUCTURE; GENE FAMILY; ACTIVATION; MUTATIONS; ESTROGEN; MEMBER;
Keywords:
WNT; Frizzled; beta-catenin; gastric cancer; NF-kappa B; Helicobacter pylori;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Katoh, M Natl Canc Ctr, Res Inst, Genet & Cell Biol Sect, Div Genet,Chuo Ku, Tsukiji 5 Chome, Tokyo 1040045, Japan Natl Canc Ctr Tsukiji 5 Chome Tokyo Japan 1040045 1040045, Japan
Citazione:
H. Kirikoshi et al., "Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT-14 by IFN gamma and up-regulation of WNT14B by beta-estradiol", INT J ONCOL, 19(6), 2001, pp. 1221-1225

Abstract

WNT proteins play key roles in carcinogenesis. We have previously cloned and characterized WNT14 and WNT14B/WNT15. WNT14 and WNT3A genes are clustered on human chromosome 1q42, while WNT14B and WNT3 genes are clustered on human chromosome 17q21. Here, we investigated expression of WNT14 and WNT14B mRNAs in human cancer. WNT14 was significantly up-regulated in 1 out of 9 cases of primary breast cancer. WNT14B was not expressed in primary breast, gastric and colorectal cancers. Among 3 human breast cancer cell lines, WNT14 mRNA was expressed in T-47D cells, and weakly expressed in MCF-7 cells. WNT14 mRNA was also detected in 7 out of 7 pancreatic cancer cell lines, 12out of 12 esophageal cancer cell lines, 4 out of 4 cervical cancer cell lines, and 5 out of 7 brain tumor cell lines by using cDNA-PCR. These resultsindicate that WNT14 rather than WNT14B is preferentially expressed in various types of human cancer, such as breast cancer, gastric cancer, and pancreatic cancer. WNT14 mRNA was up-regulated by inferferon gamma (IFN gamma), but not by tumor necrosis factor alpha (TNF alpha), in MKN45 cells derived from gastric cancer, while expression of WNT14B mRNA was not affected by IFN gamma and TNF alpha in MKN45 cells. Although expression of WNT14 mRNA wasnot affected by beta -estradiol in MCF-7 cells, WNT14B mRNA was transiently up-regulated by beta -estradiol in MCF-7 cells. These results indicate that WNT14 is a target gene of IFN gamma in MKN45 cells, and that WNT14B is atarget gene of estrogen in MCF-7 cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:34:52