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Titolo:
Detection of mRNA expression of gonadotropin-releasing hormone and its receptor in normal and neoplastic rat prostates
Autore:
Lau, HL; Zhu, XM; Leung, PCK; Chan, LW; Chen, GF; Chan, PSF; Yu, KL; Chan, FL;
Indirizzi:
Chinese Univ Hong Kong, Dept Anat, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China Chinese Univ Hong Kong, Dept Surg, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China Univ Hong Kong, Dept Zool, Hong Kong, Hong Kong, Peoples R China Univ HongKong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Univ British Columbia, Dept Obstet & Gynecol, Vancouver, BC V6H 3V5, Canada Univ British Columbia Vancouver BC Canada V6H 3V5 ver, BC V6H 3V5, Canada
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 6, volume: 19, anno: 2001,
pagine: 1193 - 1201
SICI:
1019-6439(200112)19:6<1193:DOMEOG>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER CELL-LINES; EPIDERMAL GROWTH-FACTOR; MESSENGER-RIBONUCLEIC-ACID; HIGH-AFFINITY BINDING; HUMAN OVARIAN-CANCER; GENE-EXPRESSION; ANTAGONIST CETRORELIX; GNRH RECEPTOR; HUMAN-BREAST; TUMOR-CELLS;
Keywords:
GnRH; GnRH receptor; LHRH; Dunning prostatic adenocarcinoma; androgen-independent prostatic tumor; Noble rat model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Chan, FL Chinese Univ Hong Kong, Dept Anat, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China R China
Citazione:
H.L. Lau et al., "Detection of mRNA expression of gonadotropin-releasing hormone and its receptor in normal and neoplastic rat prostates", INT J ONCOL, 19(6), 2001, pp. 1193-1201

Abstract

Hypothalamic gonadotropin-releasing hormone (GnRH) plays a central role inthe regulation of the mammalian reproductive systems as a releasing hormone of pituitary gonadotropins. However, a number of studies have shown that GnRH or its receptor are also expressed in some reproductive organs including prostate gland, mammary gland, ovary and placenta, tumors and tumor celllines derived from these organs, suggesting that this peptide hormone may have other extrapituitary functions in addition to its role as a gonadotropin-releasing hormone. Moreover, it has been demonstrated that GnRH analogs exert some direct inhibitory effects on the proliferation of human and rat prostate cancer cells, probably mediated by its own specific receptors expressed in these tumor cells. In the present study, we investigated the mRNA expression of GnRH and its receptor in normal Noble rat prostate gland, andin three rat models of prostate cancer including the sex hormone-induced Noble rat model, an androgen-independent Noble rat prostatic tumor (AIT) andDunning rat prostatic adenocarcinomas by RT-PCR and Southern blot analyses. The results showed that GnRH mRNA was expressed in the normal, hormone-treated and neoplastic rat prostates, in addition to its positive control expression in the hypothalamus, whereas its receptor was only detected in the androgen-dependent Dunning R3327H tumor. The detection of both GnRH and itsreceptor in the androgen-dependent Dunning R3327H tumor tissue suggests that this peptide hormone may have some autocrine and paracrine regulatory functions in this tumor. However, the gene expression of GnRH receptor was not detected in two androgen-independent Dunning tumor sublines and the Noblerat prostatic tumor, AIT, suggesting that the expression of GnRH receptor is lost or down-regulated in the prostatic tumors during the progression toa hormone-independent phenotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:54:22