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Titolo:
Molecular cloning and characterization of LZIC, a novel gene encoding ICAThomologous protein with leucine zipper domain
Autore:
Katoh, M;
Indirizzi:
Natl Canc Ctr, Res Inst, Div Genet, Genet & Cell Biol Sect, Tokyo 1040045,Japan Natl Canc Ctr Tokyo Japan 1040045 & Cell Biol Sect, Tokyo 1040045,Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 6, volume: 8, anno: 2001,
pagine: 611 - 615
SICI:
1107-3756(200112)8:6<611:MCACOL>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMOSOMAL LOCALIZATION; BETA-CATENIN; ALLELIC LOSS; CANCER; HETEROZYGOSITY; 1P36; IDENTIFICATION; PROGRESSION; EXPRESSION; CARCINOMA;
Keywords:
WNT; Frizzled; beta-catenin; gastric cancer; esophageal cancer; pancreatic cancer; bioinformatics; TCF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Katoh, M Natl Canc Ctr Res Inst, Genet & Cell Biol Sect, Chuo Ku, Tsukiji 5 Chome, Tokyo 1040045, Japan Natl Canc Ctr Res Inst Tsukiji 5 Chome TokyoJapan 1040045 Japan
Citazione:
M. Katoh, "Molecular cloning and characterization of LZIC, a novel gene encoding ICAThomologous protein with leucine zipper domain", INT J MOL M, 8(6), 2001, pp. 611-615

Abstract

ICAT inhibits the interaction between beta -catenin and TCF transcription factors. As ICAT might be a tumor suppressor gene with the potential to negatively regulate the WNT - beta -catenin - TCF signaling pathway, ICAT related gene in the human genome draft sequence was searched for. Here, the LZIC gene, a novel gene encoding a 190-amino-acid polypeptide with leucine zipper domain and ICAT homoloclous domain, was cloned and characterized. Amino-acid identity between LZIC and ICAT in the ICAT homologous domain was 38%. The LZIC gene, consisting of at least 8 exons, was located in the human chromosome Ip36.32-pter region. The major 5.2-kb LZIC mRNA and minor 2.1-, 1.6-, and 1.0-kb LZIC mRNAs. were expressed almost ubiquitously in normal human tissues. LZIC was expressed in all cancer cell lines examined in this study, and was significantly up-regulated in a gastric cancer cell line MKN74and 5 cases of primary gastric cancer. As LZIC contains ICAT homologous. domain, LZIC might inhibit the interaction between beta -catenin and TCF transcription factors, just like ICAT, and, up-regulation of LZIC in gastric cancer might be due to a negative feed-back mechanism to inhibit the WNT - beta -catenin - TCF signaling, pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 04:43:46