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Titolo:
Memory self-appraisal and depressive symptoms in people at genetic risk for Alzheimer's disease
Autore:
Small, GW; Chen, ST; Komo, S; Ercoli, L; Miller, K; Siddarth, P; Kaplan, A; Dorsey, D; Lavretsky, H; Saxena, S; Bookheimer, SY;
Indirizzi:
Univ Calif Los Angeles, Inst Neuropsychiat, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Alzheimers Dis Ctr, Los Angeles, CA 90024 USA UnivCalif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Ctr Aging, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA Ctr Aging, Los Angeles, CA USA VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA VA Greater LosAngeles Healthcare Syst Los Angeles CA USA ngeles, CA USA
Titolo Testata:
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
fascicolo: 11, volume: 16, anno: 2001,
pagine: 1071 - 1077
SICI:
0885-6230(200111)16:11<1071:MSADSI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATE-ONSET DEPRESSION; LATE-LIFE DEPRESSION; E ALLELE EPSILON-4; APOLIPOPROTEIN-E; OLDER ADULTS; FUNCTIONING QUESTIONNAIRE; COGNITIVE CHANGE; ASSOCIATION; COMMUNITY; PERFORMANCE;
Keywords:
subjective memory; apolipoprotein E-4; depressive symptoms; memory self-appraisal; age-related cognitive decline; memory complaint;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Small, GW Univ Calif Los Angeles, Inst Neuropsychiat, 760 Westwood Plaza,Room 88-201, Los Angeles, CA 90024 USA Univ Calif Los Angeles 760 Westwood Plaza,Room 88-201 Los Angeles CA USA 90024
Citazione:
G.W. Small et al., "Memory self-appraisal and depressive symptoms in people at genetic risk for Alzheimer's disease", INT J GER P, 16(11), 2001, pp. 1071-1077

Abstract

Objective A previous study found that subjective memory loss in middle-aged and older persons is associated with the major genetic risk for Alzheimer's disease, the apolipoprotein E-4 (APOE-4) allele. No previous study has focused on subjective memory complaints and depressive symptoms in the same subject population at genetic risk for Alzheimer's disease. Method Sixty-six persons (mean age = 64 years, range = 43 to 82 years) without major depression or dementia but with mild age-related memory complaints were rated for severity of depressive symptoms, using the Hamilton Depression Rating Scale, and assessed for the presence of the APOE-4 allele. Severity of subjective memory loss was assessed using the Memory Functioning Questionnaire, which measures four memory domains: frequency of forgetting, seriousness of forgetting, retrospective functioning, and mnemonics usage. Results Depressive symptoms were significantly associated with subjective memory loss in subjects without the APOE-4 allele, for retrospective functioning (perceived change in memory) and mnemonics usage, but not in APOE-4 carriers. The same significant associations were found when the analysis waslimited to the 44 subjects in the mid-age range (55-74 years), wherein APOE-4 confers its greatest effects on risk for Alzheimer's disease. Conclusions These results confirm that mild depressive symptoms are related to subjective memory loss, but for some forms of memory complaint, the relationship holds true only for people without the major known genetic risk for Alzheimer's disease. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:25:00