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Titolo:
Prevention of Porphyromonas gingivalis-induced oral bone loss following immunization with gingipain R1
Autore:
Gibson, FC; Genco, CA;
Indirizzi:
Boston Univ, Sch Med, Dept Med, Infect Dis Sect, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 ed, Infect Dis Sect, Boston, MA 02118 USA
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 12, volume: 69, anno: 2001,
pagine: 7959 - 7963
SICI:
0019-9567(200112)69:12<7959:POPGOB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED PERIODONTAL-DISEASE; BACTEROIDES-GINGIVALIS; CYSTEINE PROTEINASES; GNOTOBIOTIC-RATS; INACTIVATION; ARGININE; MICE; PATHOGENESIS; RESPONSES; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Gibson, FC Boston Univ, Sch Med, Dept Med, Infect Dis Sect, 650 Albany St,Boston, MA02118 USA Boston Univ 650 Albany St Boston MA USA 02118 ston, MA02118 USA
Citazione:
F.C. Gibson e C.A. Genco, "Prevention of Porphyromonas gingivalis-induced oral bone loss following immunization with gingipain R1", INFEC IMMUN, 69(12), 2001, pp. 7959-7963

Abstract

The arginine gingipains RgpA and RgpB of Porphyromonas gingivalis are well-documented virulence factors of this organism. Structurally, RgpA and RgpBhave nearly identical catalytic domains, while RgpA possesses an additional hemagglutinin domain. In this study, we examined the abilities of these proteins to elicit protection against A gingivalis-mediated oral bone loss In a murine oral challenge model. Mice immunized subcutaneously with heat-killed A gingivalis or purified RgpA or RgpB possessed elevated levels of P. gingivalis-specific Immunoglobulin G; however, only the animals immunized with P. gingivalis whole cells or RgpA were protected from maxillary bone loss. These data suggest that immunization with RgpA stimulates the production of hemagglutinin domain-specific antibodies, which contribute to the prevention of P. gingivalis-mediated periodontal disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 05:49:20