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Titolo:
Pneumococcal conjugate vaccines overcome splenic dependency of antibody response to pneumococcal polysaccharides
Autore:
Breukels, MA; Zandvoort, A; van den Dobbelsteen, GPJM; van den Muijsenberg, A; Lodewijk, ME; Beurret, M; Klok, PA; Timens, W; Rijkers, GT;
Indirizzi:
Univ Utrecht, Wilhelmina Childrens Hosp, Med Ctr, Dept Pediat Immunol, NL-3584 EA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 EA 3584 EA Utrecht, Netherlands Univ Groningen Hosp, Dept Pathol, NL-9713 GZ Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9713 GZ ningen, Netherlands Natl Inst Publ Hlth & Environm, Lab Vaccine Res, NL-3721 MA Bilthoven, Netherlands Natl Inst Publ Hlth & Environm Bilthoven Netherlands NL-3721 MA herlands
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 12, volume: 69, anno: 2001,
pagine: 7583 - 7587
SICI:
0019-9567(200112)69:12<7583:PCVOSD>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-WALL POLYSACCHARIDE; ZONE B-CELLS; IMMUNE-RESPONSE; CAPSULAR POLYSACCHARIDE; SPLENECTOMIZED CHILDREN; T-CELLS; INFANTS; DISEASE; SPLEEN; IGG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Breukels, MA Univ Utrecht, Wilhelmina Childrens Hosp, Med Ctr, Dept PediatImmunol, KC03-068-0,Lundlaan 6, NL-3584 EA Utrecht, Netherlands Univ Utrecht KC03-068-0,Lundlaan 6 Utrecht Netherlands NL-3584 EA
Citazione:
M.A. Breukels et al., "Pneumococcal conjugate vaccines overcome splenic dependency of antibody response to pneumococcal polysaccharides", INFEC IMMUN, 69(12), 2001, pp. 7583-7587

Abstract

Protection against infectious with Streptococcus pneumoniae depends on thepresence of antibodies against capsular polysaccharides that facilitate phagocytosis. Asplenic patients are at increased risk for pneumococcal infections, since both phagocytosis and the initiation of the antibody response to polysaccharides take place in the spleen. Therefore, vaccination with pneumococcal polysaccharide vaccines is recommended prior to splenectomy, which, as in the case of trauma, is not always feasible. We show that in rats, vaccination with a pneumococcal conjugate vaccine can induce good antibody responses even after splenectomy, particularly after a second dose. The spleen remains necessary for a fast, primary response to (blood-borne) polysaccharides, even when they are presented in a conjugated form. Coadministration of a conjugate vaccine with additional nonconjugated polysaccharides of other serotypes did not improve the response to the nonconjugated polysaccharides. We conclude that pneumococcal conjugate vaccines can be of value inprotecting asplenic or hyposplenic patients against pneumococcal infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:59:44