Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of 6-hydroxydopamine on host resistance against Listeria monocytogenes infection
Autore:
Miura, T; Kudo, T; Matsuki, A; Sekikawa, K; Tagawa, YI; Iwakura, Y; Nakane, A;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Bacteriol, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Hirosaki Univ, Sch Med, Dept Anesthesiol, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Hirosaki Univ, Sch Hlth Sci, Dept Med Technol, Hirosaki, Aomori 036, JapanHirosaki Univ Hirosaki Aomori Japan 036 hnol, Hirosaki, Aomori 036, Japan Natl Inst Anim Hlth, Dept Immunol, Tsukuba, Ibaraki 305, Japan Natl Inst Anim Hlth Tsukuba Ibaraki Japan 305 Tsukuba, Ibaraki 305, Japan Shinshu Univ, Sch Med, Inst Expt Anim, Matsumoto, Nagano 390, Japan Shinshu Univ Matsumoto Nagano Japan 390 nim, Matsumoto, Nagano 390, Japan Univ Tokyo, Inst Med Sci, Ctr Med Expt, Tokyo, Japan Univ Tokyo Tokyo Japan Tokyo, Inst Med Sci, Ctr Med Expt, Tokyo, Japan
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 12, volume: 69, anno: 2001,
pagine: 7234 - 7241
SICI:
0019-9567(200112)69:12<7234:EO6OHR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NERVOUS-SYSTEM MODULATION; IMMUNE-SYSTEM; CHEMICAL SYMPATHECTOMY; T-CELL; CYTOKINE PRODUCTION; IN-VIVO; LYMPHOID ORGANS; DEFICIENT MICE; MURINE THYMUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Nakane, A Hirosaki Univ, Sch Med, Dept Bacteriol, Zaifu Cho 5, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Zaifu Cho 5 Hirosaki Aomori Japan 0368562 2, Japan
Citazione:
T. Miura et al., "Effect of 6-hydroxydopamine on host resistance against Listeria monocytogenes infection", INFEC IMMUN, 69(12), 2001, pp. 7234-7241

Abstract

Recent studies have shown that immunocompetent cells bear receptors of neuropeptides and neurotransmitters and that these ligands play roles in the immune response. In this study, the role of the sympathetic nervous system in host resistance against Listeria monocytogenes infection was investigatedin mice pretreated with 6-hydroxydopamine (6-OHDA), which destroys sympathetic nerve termini. The norepinephrine contents of the plasma and spleens were significantly lower in 6-OHDA-treated mice than in vehicle-treated mice. The 50% lethal dose of L. monocytogenes was about 20 times higher for 6-OHDA-treated mice than for vehicle-treated mice. Chemical sympathectomy by 6-OHDA upregulated interleukin-12 (IL-12) and tumor necrosis factor-alpha (TNF-alpha) production in enriched dendritic cell cultures and gamma interferon (IFN-gamma) and TNF-alpha production in spleen cell cultures, whereas chemical sympathectomy had no apparent effect on phagocytic activities, listericidal activities, and nitric oxide production in peritoneal exudate cellsand splenic macrophages. Augmentation of host resistance against L. monocytogenes infection by 6-OHDA was abrogated in IFN-gamma (-/-) or TNF-alpha (-/-) mice, suggesting that upregulation of IFN-gamma, IL-12, and TNF-alpha production may be involved in 6-OHDA-mediated augmentation of antilisterialresistance. Furthermore, adoptive transfer of spleen cells immune to L. monocytogenes from 6-OHDA-treated mice resulted in untreated naive recipientsthat had a high level of resistance against L. monocytogenes infection. These results suggest that the sympathetic nervous system may modulate host resistance against L. monocytogenes infection through regulation of production of IFN-gamma, IL-12, and TNF-alpha, which are critical in antilisterial resistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 16:55:35