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Titolo:
Epithelial cells infected with Chlamydophila pneumoniae (Chlamydia pneumoniae) are resistant to apoptosis
Autore:
Rajalingam, K; Al-Younes, H; Muller, A; Meyer, TF; Szczepek, AJ; Rudel, T;
Indirizzi:
Max Planck Inst Infect Biol, Dept Biol Mol, D-10117 Berlin, Germany Max Planck Inst Infect Biol Berlin Germany D-10117 10117 Berlin, Germany
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 12, volume: 69, anno: 2001,
pagine: 7880 - 7888
SICI:
0019-9567(200112)69:12<7880:ECIWCP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CYTOCHROME-C RELEASE; NF-KAPPA-B; III SECRETION; YERSINIA-ENTEROCOLITICA; BACTERIAL PATHOGENS; TARGET-CELLS; PORIN PORB; MACROPHAGES; DEATH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Meyer, TF Max Planck Inst Infect Biol, Dept Biol Mol, Schumannstr 21-22, D-10117 Berlin, Germany Max Planck Inst Infect Biol Schumannstr 21-22 Berlin Germany D-10117
Citazione:
K. Rajalingam et al., "Epithelial cells infected with Chlamydophila pneumoniae (Chlamydia pneumoniae) are resistant to apoptosis", INFEC IMMUN, 69(12), 2001, pp. 7880-7888

Abstract

The obligate intracellular pathogen Chlamydophila pneumoniae (Chlamydia pneumoniae) initiates infections in humans via the mucosal epithelia of the respiratory tract. Here, we report that epithelial cells infected with C pneumoniae are resistant to apoptosis induced by treatment with drugs or by death receptor ligation. The induction of protection from apoptosis depended on the infection conditions since only cells containing large inclusions were protected. The underlying mechanism of infection-induced apoptosis resistance probably involves mitochondria, the major integrators of apoptotic signaling. In the infected cells, mitochondria did not respond to apoptotic stimuli by the release of apoptogenic factors required for the activation ofcaspases. Consequently, active caspase-3 was absent in infected cells. Ourdata suggest a direct modulation of apoptotic pathways in epithelial cellsby C pneumoniae.

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Documento generato il 04/12/20 alle ore 22:39:47