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Titolo:
CD8(+)CD28(-) T suppressor cells and the induction of antigen-specific, antigen-presenting cell-mediated suppression of Th reactivity
Autore:
Cortesini, R; LeMaoult, J; Ciubotariu, R; Cortesini, NSF;
Indirizzi:
Columbia Univ, Dept Pathol, New York, NY 10032 USA Columbia Univ New YorkNY USA 10032 , Dept Pathol, New York, NY 10032 USA
Titolo Testata:
IMMUNOLOGICAL REVIEWS
, volume: 182, anno: 2001,
pagine: 201 - 206
SICI:
0105-2896(200108)182:<201:CTSCAT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; SELF-TOLERANCE; AUTOIMMUNE-DISEASE; IN-VITRO; RESPONSES; SUBSET; MECHANISM; MICE; ACTIVATION; RECEPTORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Cortesini, NSF Columbia Univ, Dept Pathol, 630 W 168 St,P&S 14-401, New York, NY 10032 USA Columbia Univ 630 W 168 St,P&S 14-401 New York NY USA 10032
Citazione:
R. Cortesini et al., "CD8(+)CD28(-) T suppressor cells and the induction of antigen-specific, antigen-presenting cell-mediated suppression of Th reactivity", IMMUNOL REV, 182, 2001, pp. 201-206

Abstract

Human CD8(+)CD28(-) suppressor T cells (Ts) are a subset of T cells generated in the course of in vitro and in vivo immunizations. Ts recognize MHC class I:peptide complexes and inhibit the reactivity of T helper cells (Th) with cognate antigen specificity. We have demonstrated for the first time that CD8(+)CD28(-) Ts represent a unique subset of regulatory cells that induces the differentiation of tolerogenic antigen-presenting cells, initiating a Suppressive loop which results in the induction and spreading of Th unresponsiveness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:35:11