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Titolo:
Control of intestinal inflammation by regulatory T cells
Autore:
Singh, B; Read, S; Asseman, C; Malmstrom, V; Mottet, C; Stephens, LA; Stepankova, R; Tlaskalova, H; Powrie, F;
Indirizzi:
Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England Univ Oxford Oxford England OX1 3RE n Sch Pathol, Oxford OX1 3RE, England Acad Sci Czech Republ, Div Immunol & Gnotobiol, Prague, Czech Republic Acad Sci Czech Republ Prague Czech Republic iol, Prague, Czech Republic
Titolo Testata:
IMMUNOLOGICAL REVIEWS
, volume: 182, anno: 2001,
pagine: 190 - 200
SICI:
0105-2896(200108)182:<190:COIIBR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOLOGICAL SELF-TOLERANCE; GROWTH-FACTOR-BETA; LYMPHOCYTE-ASSOCIATED ANTIGEN-4; HUMAN DENDRITIC CELLS; BOWEL-DISEASE; AUTOIMMUNE-DISEASE; SCID MICE; INTERLEUKIN-2-DEFICIENT MICE; HELICOBACTER-HEPATICUS; CHRONIC ENTEROCOLITIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Powrie, F Univ Oxford, Sir William Dunn Sch Pathol, S Parks Rd, Oxford OX13RE, England Univ Oxford S Parks Rd Oxford England OX1 3RE OX1 3RE, England
Citazione:
B. Singh et al., "Control of intestinal inflammation by regulatory T cells", IMMUNOL REV, 182, 2001, pp. 190-200

Abstract

Transfer of CD4(+) T cells to immune-deficient mice in the absence of the CD25(+) subset leads to the development of colitis, indicating that regulatory cells capable of controlling a bacteria-driven inflammatory response are present in normal mice. Cells with this function are present in the thymus as well as in the periphery of germ-free mice, suggesting they may be reactive with self-antigen. These cells resemble CD4(+)CD25(+) cells that inhibit organ-specific autoimmunity suggesting that a similar subset of regulatory T cells may control responses to self and foreign antigens. Developmentof colitis is dependent on accumulation of activated CD134L(+) dendritic cells (DC) in the mesenteric lymph nodes, which is inhibited by CD4(+)CD25(+) cells, indicating that regulatory T cells may control DC activation in vivo. Whilst inhibition of T-cell activation in vitro by CD4(+)CD25(+) cells does not involve interleukin-10 and transforming growth factor-beta, these cytokines are required for the suppression of colitis. It may be that control of responses that activate the innate immune system requires multiple mechanisms of immune suppression. Recently, we identified CD4(+)CD25(+) cellswith immune suppressive activity in the thymus and peripheral blood of humans, raising the possibility that dysfunction in thin, mechanism of immune regulation may be involved in the development of autoimmune and inflammatory diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:47:41