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Titolo:
The role of CD4(+) T-cell subsets in determining transplantation rejectionor tolerance
Autore:
Zelenika, D; Adams, E; Humm, S; Lin, CY; Waldmann, H; Cobbold, SP;
Indirizzi:
Univ Oxford, Sir William Dunn Sch Pathol, Therapeut Immunol Grp, Oxford OX1 3RE, England Univ Oxford Oxford England OX1 3RE Immunol Grp, Oxford OX1 3RE, England
Titolo Testata:
IMMUNOLOGICAL REVIEWS
, volume: 182, anno: 2001,
pagine: 164 - 179
SICI:
0105-2896(200108)182:<164:TROCTS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; LYMPHOCYTE-ASSOCIATED ANTIGEN-4; MONOCLONAL-ANTIBODIES; INFECTIOUS TOLERANCE; ALLOGRAFT-REJECTION; GENE-EXPRESSION; REGULATORY CELLS; CUTTING EDGE; CARDIAC ALLOGRAFTS; LINKED SUPPRESSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Cobbold, SP Univ Oxford, Sir William Dunn Sch Pathol, Therapeut Immunol Grp, S Parks Rd, Oxford OX1 3RE, England Univ Oxford S Parks Rd Oxford England OX1 3RE X1 3RE, England
Citazione:
D. Zelenika et al., "The role of CD4(+) T-cell subsets in determining transplantation rejectionor tolerance", IMMUNOL REV, 182, 2001, pp. 164-179

Abstract

Peripheral tolerance to allogeneic organ grafts can be induced in rodents by creating,vith non-depleting CD4 and CD8 monoclonal antibodies. This tolerance is maintained by CD4(+) T cells with a potent capacity to induce tolerance in further cohorts of T cells (i.e. infectious tolerance). We have cloned CD4(+) T-cell subsets against the male transplantation antigen in vitro and find, in contrast to Th1 or Th2 clones that elicit rejection, that there is a distinct population of CD4(+) T cells that suppress rejection by adoptive transfer (here called Treg). In order to identify molecular marketsassociated with tolerance and gain insights into the mechanisms of action of Treg cells, we carried out serial analysis of gene expression. We identified genes overexpressed in Treg compared to Th1 and Th2 cultures and foundthat some of these correlated in vivo with CD4-induced transplantation tolerance rather than rejection. The genes overexpressed in Treg cultures and within tolerated skin grafts were primarily expressed by mast cells (e,g, tryptophan hydroxylase and Fc epsilon R1 alpha), suggesting that regulatory cell activity and this form of tolerance may be associated with a localisedbut non-destructive form of Th2 like activation and a recruitment of mast cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 09:02:01