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Titolo:
An integrative model of regulation centered on recognition of TCR peptide/MHC complexes
Autore:
Kumar, V; Sercarz, E;
Indirizzi:
La Jolla Inst Allergy & Immunol, Div Immune Regulat, San Diego, CA 92121 USA La Jolla Inst Allergy & Immunol San Diego CA USA 92121 iego, CA 92121 USA
Titolo Testata:
IMMUNOLOGICAL REVIEWS
, volume: 182, anno: 2001,
pagine: 113 - 121
SICI:
0105-2896(200108)182:<113:AIMORC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL RECEPTOR; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MYELIN BASIC-PROTEIN; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; V-BETA-8.2 CHAIN; VARIABLE REGION; SELF-TOLERANCE; VACCINATION; DISEASE; RESPONSES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Kumar, V La Jolla Inst Allergy & Immunol, Div Immune Regulat, 10355 Sci Ctr Dr, SanDiego, CA 92121 USA La Jolla Inst Allergy & Immunol 10355 Sci Ctr Dr San Diego CA USA 92121
Citazione:
V. Kumar e E. Sercarz, "An integrative model of regulation centered on recognition of TCR peptide/MHC complexes", IMMUNOL REV, 182, 2001, pp. 113-121

Abstract

We have described a T-cell receptor (TCR)-centered model of immune regulation, in which MHC/TCR peptide complexes provide for the activation of regulatory T cells and likewise act as their target structures. In this model, the disease-causing effectors are TCR V beta8.2(+) and each of the required CD4 and CD8 regulatory T-cell populations are specific for different conserved regions of the V beta8,2 chain, in the appropriate MHC context. We havecharacterized the dominance, the dynamics as well as the TCR usage of botheffector and regulatory T cells. We have begun to characterize the essential elements of the regulatory program, including the mechanism of interaction among effector and regulatory T-cell populations. Principles learned in this model have important implications for immune regulation in general.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 14:44:47