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Titolo:
Immunologic tolerance maintained by CD25(+) CD4(+) regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance
Autore:
Sakaguchi, S; Sakaguchi, N; Shimizu, J; Yamazaki, S; Sakihama, T; Itoh, M; Kuniyasu, Y; Nomura, T; Toda, M; Takahashi, T;
Indirizzi:
Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 pt Pathol, Sakyo Ku, Kyoto 6068507, Japan Tokyo Metropolitan Inst Gerontol, Dept Immunopathol, Tokyo, Japan Tokyo Metropolitan Inst Gerontol Tokyo Japan Immunopathol, Tokyo, Japan Univ Tsukuba, Sch Med, Dept Dermatol, Tsukuba, Ibaraki 305, Japan Univ Tsukuba Tsukuba Ibaraki Japan 305 matol, Tsukuba, Ibaraki 305, Japan Jikei Med Univ, Dept Med, Tokyo, Japan Jikei Med Univ Tokyo JapanJikei Med Univ, Dept Med, Tokyo, Japan Mie Univ, Sch Med, Dept Immunol, Tsu, Mie 514, Japan Mie Univ Tsu Mie Japan 514 iv, Sch Med, Dept Immunol, Tsu, Mie 514, Japan
Titolo Testata:
IMMUNOLOGICAL REVIEWS
, volume: 182, anno: 2001,
pagine: 18 - 32
SICI:
0105-2896(200108)182:<18:ITMBCC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTE-ASSOCIATED ANTIGEN-4; RECEPTOR TRANSGENIC MICE; GROWTH-FACTOR-BETA; CLASS-II MOLECULES; SELF-TOLERANCE; MONOCLONAL-ANTIBODY; ALLERGIC ENCEPHALOMYELITIS; INTESTINAL INFLAMMATION; DIABETES-MELLITUS; EFFECTOR FUNCTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Sakaguchi, S Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Sakyo Ku, 53 Shogoin Kawahara Cho, Kyoto 6068507, Japan Kyoto Univ 53 Shogoin Kawahara Cho Kyoto Japan 6068507 Japan
Citazione:
S. Sakaguchi et al., "Immunologic tolerance maintained by CD25(+) CD4(+) regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance", IMMUNOL REV, 182, 2001, pp. 18-32

Abstract

There is accumulating evidence that T-cell-mediated dominant control of self-reactive T-cells contributed, to the maintenance of immunologic self-tolerance and its alteration can cause autoimmune disease. Efforts to delineate such a regulatory T-cell population have revealed that CD25(+) cells in the CD4(+) population in normal naive animals bear the ability to prevent autoimmune disease in vivo and, upon antigenic stimulation, suppress the activation/proliferation of other T cells in vitro, The CD25(+) CD4(+) regulatory T cells, which are naturally anergic and suppressive, appear to be produced by the normal thymus as a functionally distinct subpopulation of T cells. They play critical roles not only in preventing autoimmunity but also incontrolling tumor immunity and transplantation tolerance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 09:19:06