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Titolo:
Existence of TT virus DNA and TTV-like mini virus DNA in infant cord blood: mother-to-neonatal transmission
Autore:
Matsubara, H; Michitaka, K; Horiike, N; Kihana, T; Yano, M; Mori, T; Onji, M;
Indirizzi:
Ehime Univ, Sch Med, Dept Internal Med 3, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan Ehime Prefectural Cent Hosp, Matsuyama, Ehime, Japan Ehime Prefectural Cent Hosp Matsuyama Ehime Japan atsuyama, Ehime, Japan Matsuyama Hosp, NTT, Matsuyama, Ehime, Japan Matsuyama Hosp Matsuyama Ehime Japan Hosp, NTT, Matsuyama, Ehime, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 3, volume: 21, anno: 2001,
pagine: 280 - 287
SICI:
1386-6346(200111)21:3<280:EOTVDA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTHY JAPANESE SUBJECTS; POSTTRANSFUSION HEPATITIS; UNKNOWN ETIOLOGY; HIGH PREVALENCE; NON-A; INFECTION; CHILDREN; DONORS;
Keywords:
TT virus; TTV-like mini virus; vertical transmission; cord blood; amniotic fluids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Michitaka, K Ehime Univ, Sch Med, Dept Internal Med 3, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 hime 7910295, Japan
Citazione:
H. Matsubara et al., "Existence of TT virus DNA and TTV-like mini virus DNA in infant cord blood: mother-to-neonatal transmission", HEPATOL RES, 21(3), 2001, pp. 280-287

Abstract

The route of transmission of TT virus (TTV) was studied by examining the existence of TTV DNA in different body fluids from the new born infants and their mothers. A total of 52 pregnant women with normal serum alanine aminotransferase levels were enrolled in this study. TTV DNA was examined using a polymerase chain reaction method using Takahashi's primers which can detect all genotypes of TTV and Okamoto's primers which detect only some of thegenotypes of TTV. TTV DNA was detected in the sera from 40/52 (77%), in the breast milk from 35/52 (67%), and in the amniotic fluid from 6/6 (100%) pregnant mothers using Takahashi's primers TTV DNA was also detected in the sera from 8 of 11 (73%) and in the cord blood from 25/52 (48%) new born infants using Takahashi's primers. However, TTV DNA was detected in only 5/52 maternal blood (10%) and 4/52 breast milk (8%) using Okamoto's primers. Allsamples positive for TTV DNA by Takahashi's primers, were also positive for TTV-like mini virus (TLMV) DNA. Our data suggest that intrauterine transmission or transmission via breast milk may contribute to maintaining the global TTV and TLMV reservoir. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:20:50