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Titolo:
Serum leptin concentrations in liver cirrhosis: relationship to the severity of liver dysfunction and their characteristic diurnal profiles
Autore:
Onodera, K; Kato, A; Suzuki, K;
Indirizzi:
Iwate Med Univ, Sch Med, Dept Internal Med 1, Morioka, Iwate 0208505, Japan Iwate Med Univ Morioka Iwate Japan 0208505 Morioka, Iwate 0208505, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 3, volume: 21, anno: 2001,
pagine: 205 - 212
SICI:
1386-6346(200111)21:3<205:SLCILC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA LEPTIN; OBESE GENE; ALCOHOLIC CIRRHOSIS; INSULIN SENSITIVITY; CHRONIC HEPATITIS; BODY-WEIGHT; HUMANS; EXPRESSION; PRODUCT; MOUSE;
Keywords:
leptin; liver cirrhosis; body composition analysis; body mass index (BMI); gender differences; circadian rhythmicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Kato, A Iwate Med Univ, Sch Med, Dept Internal Med 1, 19-1 Uchimaru, Morioka, Iwate 0208505, Japan Iwate Med Univ 19-1 Uchimaru Morioka Iwate Japan 0208505 05, Japan
Citazione:
K. Onodera et al., "Serum leptin concentrations in liver cirrhosis: relationship to the severity of liver dysfunction and their characteristic diurnal profiles", HEPATOL RES, 21(3), 2001, pp. 205-212

Abstract

Liver cirrhosis is often associated with malnutrition status, and while leptin, which reduces food intake, appears to contribute to it, there have been few detailed studies of serum leptin concentrations in cases of liver cirrhosis. We therefore measured serum leptin concentrations in liver cirrhosis and investigated its relationship with gender, body composition analysis, and the severity of liver dysfunction and the patterns of diurnal profiles in serum leptin. There were no significant differences between the serum leptin concentrations in the healthy controls and patients with liver cirrhosis. The serum leptin concentrations in liver cirrhosis cases were significantly higher in females than in males. Significant positive correlations were observed between the serum leptin and the body composition analysis data such as body mass index (BMI), arm circumference (AC), and triceps skin fold thickness (TSF). There was no correlations between BMI and arm muscle circumference (AMC). No changes in leptin levels were observed in association with the progression of liver dysfunction, according to the Child-Pugh classification. The diurnal profiles showed different patterns in liver cirrhosis and diabetes mellitus. In diabetes, a nocturnal rise was seen beginning around 21:00, but in liver cirrhosis, the rise in serum leptin started around 12:00, peaked at 13:00, and remained elevated until 03:00 in the morning. No associations were observed between the variations in serum leptin concentrations and variations in blood glucose or plasma insulin levels. In summary, serum leptin concentrations in liver cirrhosis are higher in women,positively correlated with the body composition analysis data, but not correlated with the severity of liver dysfunction. The diurnal profiles in serum leptin concentrations in liver cirrhosis also showed a different patternfrom the profiles in diabetes with the values starting to increase earlier, during the daytime. Further study regarding the relation of leptin to nutrition and metabolic abnormalities in liver cirrhosis appears to be necessary. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:10:03