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Titolo:
Calcium channels triggering transmitter release in the rat medial superiorolive
Autore:
Barnes-Davies, M; Owens, S; Forsythe, ID;
Indirizzi:
Univ Leicester, Dept Cell Physiol & Pharmacol, Ion Channel Grp, Leicester LE1 9HN, Leics, England Univ Leicester Leicester Leics England LE1 9HN er LE1 9HN, Leics, England
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 162, anno: 2001,
pagine: 134 - 145
SICI:
0378-5955(200112)162:1-2<134:CCTTRI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTEROVENTRAL COCHLEAR NUCLEUS; CENTRAL SYNAPTIC TRANSMISSION; AUDITORY BRAIN-STEM; DEVELOPMENTAL-CHANGES; TRAPEZOID BODY; DELAY-LINES; NEURONS; PROJECTIONS; TERMINALS; PROTEINS;
Keywords:
medial superior olive; medial nucleus of the trapezoid body; anterior ventral cochlear nucleus; voltage-gated calcium current; glutamate; glycine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Barnes-Davies, M Univ Leicester, Dept Cell Physiol & Pharmacol, Ion Channel Grp, POB 138, Leicester LE1 9HN, Leics, England Univ Leicester POB 138 Leicester Leics England LE1 9HN nd
Citazione:
M. Barnes-Davies et al., "Calcium channels triggering transmitter release in the rat medial superiorolive", HEARING RES, 162(1-2), 2001, pp. 134-145

Abstract

We used whole cell voltage clamp recordings from neurones in rat auditory brainstem slices to study the Ca2+ channel types involved in triggering synaptic glutamate and glycine release in the medial superior olivary nucleus. Glutamate release from the anterior ventral cochlear (aVCN) bushy neurone synapse did not involve L-type Ca2+ channels (alpha (1C-D); Ca(V)1.2-1.3), but was mediated with similar efficacies by both N-type (alpha (1B); Ca(V)2.2) and the P/Q-type Ca2+ channels (alpha (1A); Ca(V)2.1). Glycine release from the medial nucleus of the trapezoid body (MNTB) synapse was mediated predominantly by P/Q-type Ca2+ channels, but with a significant contributionfrom N-type Ca2+ Channels. Combined application of the P/Q- and N-type Ca2 channel toxins, omega -agatoxin IVA and omega -conotoxin GVIA, left a very small remnant of both the inhibitory and excitatory postsynaptic currents, probably reflecting a minimal contribution of R-type Ca2+ channels (alpha(1E); Ca(V)2.3) to transmitter release, In contrast with aVCN bushy neurones, MNTB somata lacked both T-(alpha (1G-I); Ca(V)3.1-3.3) and L-type channels, but expressed a higher proportion of P/Q-type Ca2+ channels. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:10:40