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Titolo:
In vivo visualization of the cochlear nerve and nuclei with fluorescent axonal tracers
Autore:
Marangos, N; Illing, RB; Kruger, J; Laszig, R;
Indirizzi:
Univ Freiburg, Neurobiol Res Lab, Dept Otorhinolaryngol, Freiburg, GermanyUniv Freiburg Freiburg Germany Dept Otorhinolaryngol, Freiburg, Germany Univ Freiburg, Inst Brain Res, Freiburg, Germany Univ Freiburg Freiburg Germany iburg, Inst Brain Res, Freiburg, Germany
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 162, anno: 2001,
pagine: 48 - 52
SICI:
0378-5955(200112)162:1-2<48:IVVOTC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-STEM IMPLANT; PROMONTORY STIMULATION; ACOUSTIC NEUROMA; CORTEX; PROJECTIONS; SURGERY;
Keywords:
auditory brainstem implant; axonal tracers; cochlear nucleus; Fast Blue;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Marangos, N Univ Mainz, HNO Klin, Langenbeckstr 1, D-55101 Mainz, Germany Univ Mainz Langenbeckstr 1 Mainz Germany D-55101 inz, Germany
Citazione:
N. Marangos et al., "In vivo visualization of the cochlear nerve and nuclei with fluorescent axonal tracers", HEARING RES, 162(1-2), 2001, pp. 48-52

Abstract

In recent years multichannel neuroprostheses have been developed which directly stimulate the central auditory pathway. Substantially these have beenused in cases of total hearing loss caused by neurofibromatosis type 2 where bilateral damage to the auditory nerve prevents more peripheral stimulation. The electrode carrier of the auditory brainstem implant (ABI) is designed to be placed on the cochlear nucleus complex residing at the lateral brainstem surface. Despite altered anatomy due to tumor growth or preceding surgery, correct electrode placement is essential to maximize the variety ofpitch percept elicited during electrical stimulation with the ABI without producing side-effects. In order to assist intraoperative identification ofthe proximal auditory nerve and cochlear nuclei, the non-toxic fluorescentaxonal tracers Fast Blue or Fluorogold were injected into the cochlea of rats and Java monkeys. Four to seven days after tracer application, labelingof the eighth cranial nerve, its entrance into the brainstem and the primary radiation of auditory fibers into the cochlear nucleus could be demonstrated as colored fluorescence on the living brain under appropriate ultraviolet illumination. Additional histological processing revealed groups of retrogradely labeled neuronal cell bodies in both species. Our results suggestthat this method could also be used in humans in order to aid surgeons with the proper positioning of the electrode array. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:26:17