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Titolo:
Distribution of protein motors along the lateral wall of the outer hair cell
Autore:
Wada, H; Usukura, H; Takeuchi, S; Sugawara, M; Kakehata, S; Ikeda, K;
Indirizzi:
Tohoku Univ, Dept Mech Engn, Sendai, Miyagi 9808579, Japan Tohoku Univ Sendai Miyagi Japan 9808579 gn, Sendai, Miyagi 9808579, Japan Tohoku Univ, Grad Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Sendai,Miyagi 9808579, Japan Tohoku Univ Sendai Miyagi Japan 9808579 urg, Sendai,Miyagi 9808579, Japan
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 162, anno: 2001,
pagine: 10 - 18
SICI:
0378-5955(200112)162:1-2<10:DOPMAT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOTILITY VOLTAGE SENSOR; COCHLEAR AMPLIFIER; MECHANICAL RESPONSES; FREQUENCY LIMIT; MEMBRANE;
Keywords:
outer hair cell; protein motor; distribution; lateral wall; microsphere;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Wada, H Tohoku Univ, Dept Mech Engn, Aoba Yama 01, Sendai, Miyagi 9808579,Japan Tohoku Univ Aoba Yama 01 Sendai Miyagi Japan 9808579 808579, Japan
Citazione:
H. Wada et al., "Distribution of protein motors along the lateral wall of the outer hair cell", HEARING RES, 162(1-2), 2001, pp. 10-18

Abstract

The outer hair cell (OHC) plays an important role in the normal functioning of the cochlea, and cochlear amplification is believed to be based on OHCelectromotility. This electromotility putatively arises from a conformational change of molecules, i.e., 'protein motors', which would be distributedalong the plasma membrane. Although it has been assumed that protein motors are distributed in a restricted area of the plasma membrane, details of such distribution remain unclarified. In this study, first, in order to understand the difference in the stiffness along the cell axis, the local deformation of the OHC in response to hypotonic stimulation is analyzed by measuring the displacement of microspheres attached randomly to the lateral wallof the cell. As a result, the stiffness is expected to be constant throughout the region except in the apical part of the cell, and the stiffness of the apical part is expected to be higher than that of the other regions. Then, the local elongation and contraction of the OHC in response to sinusoidal voltage stimulation are analyzed by measuring the displacement of the microspheres in the same way as in the case of the hypotonic stimulation. From the two measurements mentioned above, it is concluded that there are no motors in the apical and basal parts of the cell, and that the motors are equally distributed along the cell lateral wall in the middle part of the cell. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:43:18