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Titolo:
Imperatoxin A (IpTx(a)) from Pandinus imperator stimulates [H-3]ryanodine binding to RyR3 channels
Autore:
Simeoni, I; Rossi, D; Zhu, XH; Garcia, J; Valdivia, HH; Sorrentino, V;
Indirizzi:
Univ Siena, Dept Neurosci, Mol Med Sect, I-53100 Siena, Italy Univ Siena Siena Italy I-53100 rosci, Mol Med Sect, I-53100 Siena, Italy Univ Wisconsin, Dept Physiol, Sch Med, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 ysiol, Sch Med, Madison, WI 53706 USA Univ Illinois, Coll Med, Dept Physiol & Biophys, Chicago, IL USA Univ Illinois Chicago IL USA ed, Dept Physiol & Biophys, Chicago, IL USA Ist Sci San Raffaele, DIBIT, Milan, Italy Ist Sci San Raffaele Milan Italy Sci San Raffaele, DIBIT, Milan, Italy
Titolo Testata:
FEBS LETTERS
fascicolo: 1, volume: 508, anno: 2001,
pagine: 5 - 10
SICI:
0014-5793(20011109)508:1<5:IA(FPI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CA2+ RELEASE CHANNELS; CYCLIC ADP-RIBOSE; II-III LOOP; RYANODINE RECEPTOR ISOFORMS; SKELETAL-MUSCLE; DIHYDROPYRIDINE RECEPTOR; SARCOPLASMIC-RETICULUM; FREE CALCIUM; CONTRACTION; TYPE-3;
Keywords:
sarcoplasmic reticulum; excitation contraction coupling; ryanodine receptor; calcium release channel; toxin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Sorrentino, V Univ Siena, Dept Neurosci, Mol Med Sect, Via Aldo Moro 5, I-53100 Siena, Italy Univ Siena Via Aldo Moro 5 Siena Italy I-53100 Siena, Italy
Citazione:
I. Simeoni et al., "Imperatoxin A (IpTx(a)) from Pandinus imperator stimulates [H-3]ryanodine binding to RyR3 channels", FEBS LETTER, 508(1), 2001, pp. 5-10

Abstract

The effect of imperatoxin A (IpTx(a)) on the ryanodine receptor type 3 (RyR3) was studied. IpTx(a) stimulates [H-3]ryanodine binding to RyR3-containing microsomes, but this effect requires toxin concentrations higher than those required to stimulate RyR1 channels. The effect of IpTx(a) on RyR3 channels was observed at calcium concentrations in the range 0.1 muM to 10 mM. By contrast, RyR2 channels were not significantly affected by IpTx(a) in the same calcium ranges. Single channel current measurements indicated that IpTx(a) induced subconductance state in RyR3 channels that was similar to those observed with RyR1 and RyR2 channels. These results indicate that IpTx(a) is capable of inducing similar subconductance states in all three RyR isoforms, while stimulation of [H-3]ryanodine binding by this toxin results in isoform-specific responses, with RyR1 being the most sensitive channel, RyR3 displaying an intermediate response and RyR2 the least responsive ones. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation ofEuropean Biochemical Societies.

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Documento generato il 07/07/20 alle ore 12:38:55