Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Thymic hormones in cancer diagnostics and treatment
Autore:
Bodey, B;
Indirizzi:
Childrens Hosp Los Angeles, Childrens Ctr Canc & Blood Dis, Los Angeles, CA 90027 USA Childrens Hosp Los Angeles Los Angeles CA USA 90027 Angeles, CA 90027 USA Univ So Calif, Dept Pathol, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 Pathol, Los Angeles, CA 90089 USA
Titolo Testata:
EXPERT OPINION ON BIOLOGICAL THERAPY
fascicolo: 1, volume: 1, anno: 2001,
pagine: 93 - 107
SICI:
1471-2598(200101)1:1<93:THICDA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NICOTINIC ACETYLCHOLINE-RECEPTORS; TRANSCRIPTS ENCODING ALPHA-3; TUMOR-BEARING MICE; T-CELL MATURATION; EPITHELIAL-CELLS; PROTHYMOSIN-ALPHA; IN-VITRO; THYMOSIN BETA-15; PREFERENTIAL TRANSCRIPTION; MAMMALIAN THYMUS;
Keywords:
immunocytochemistry; immunoneuroendocrine regulation; intrathymic neuropeptides; intrathymic pituitary hormones; monoclonal antibodies; prothymosin alpha 1; thymic cellular microenvironment; thymic histogenesis; thymic hormones; thymic humoral factor-gamma 2; thymic reticulo-epithelial cells; thymopentin; thymosin fraction 5; thymosins;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
133
Recensione:
Indirizzi per estratti:
Indirizzo: Bodey, B 8000-1 Canby Ave, Reseda, CA 91335 USA 8000-1 Canby Ave Reseda CA USA 91335 y Ave, Reseda, CA 91335 USA
Citazione:
B. Bodey, "Thymic hormones in cancer diagnostics and treatment", EXPERT OP B, 1(1), 2001, pp. 93-107

Abstract

The thymus is an endocrine organ. A unified, physiological concept of humoral regulation of the immune response emerged in the last three decades. The thymus is the primary major site of production of immunocompetent T-lymphocytes from their haematopoietic stem cells. The thymus provides a superiorhumoral microenvironment for the development of immunocompetent T-lymphocytes. Although yolk sac derived pre-T stem cells enter the thymus using a homing receptor, the immigration process requires also secretion of a peptide, called thymotaxin by the cells of the reticulo-epithelial (RE) network. This complex process requires direct cell to cell, receptor based interactions, as well as in situ paracrine information via the numerous cytokines andthymic hormones produced by the RE cells of thymic microenvironment. Thymic hormones induce in situ T-lymphocyte marker differentiation, expression and functions. These polypeptide hormones have also been shown by means of immunocytochemistry to localise in the RE cells of the thymic cellular microenvironment. Based on the complexity of the intrathymic maturation sequenceof T-lymphocytes and the increasing numbers of T-lymphocyte subpopulationsthat are being identified, it would be surprising if a single thymic humoral factor could control all of the molecular steps and cell populations involved. Rather, it would appear that the control of intrathymic T-lymphocytematuration and functional maturation involves a complex number of thymic-specific factors and other molecules that rigidly control the intermediary steps in the differentiation process. Thymosin fraction 5 (TF5) and its component polypeptides influence a variety of lymphocyte properties including cyclic nucleotide levels, migration inhibitory factor production, T-dependent antibody production and expression of certain surface maturation/differentiation markers. Recently, thymic hormones, mostly thymosins have been employed not only in neoplasms' early detection but also in clinical trials to strengthen the effects of immunomodulators in immunodeficiencies, autoimmune diseases and neoplastic malignancies. Combined chemoimmunotherapeutical antineoplastic treatment seems to be useful. Generally, haematopoietic toxicity of every chemotherapeutical clinical trial can be reduced significantlyby the immunotherapy, compared to 50% in patients treated with chemotherapy alone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 09:09:18