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Titolo:
Heat shock proteins: novel therapeutic tools for HIV-infection?
Autore:
Brenner, BG; Wainberg, Z;
Indirizzi:
McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada McGill Univ Montreal PQ Canada H3T 1E2 Inst, Montreal, PQ H3T 1E2, Canada
Titolo Testata:
EXPERT OPINION ON BIOLOGICAL THERAPY
fascicolo: 1, volume: 1, anno: 2001,
pagine: 67 - 77
SICI:
1471-2598(200101)1:1<67:HSPNTT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; TYPE-1 ENVELOPE PROTEIN; CYCLOSPORINE-A ANALOG; CYCLOPHILIN-A; T-CELLS; IMMUNE-RESPONSES; IN-VIVO; CYCLOPENTENONE PROSTAGLANDINS; MOLECULAR CHAPERONES; PRESENTATION PATHWAY;
Keywords:
AIDS vaccines; antiviral therapy; cyclophilins; heat shock proteins; HIV-1 infection; viral-host interactions;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: Brenner, BG McGill Univ, Jewish Gen Hosp, Lady Davis Inst, 3755 Cote Ste Catherine Rd,Montreal, PQ H3T 1E2, Canada McGill Univ 3755 Cote Ste Catherine Rd Montreal PQ Canada H3T 1E2
Citazione:
B.G. Brenner e Z. Wainberg, "Heat shock proteins: novel therapeutic tools for HIV-infection?", EXPERT OP B, 1(1), 2001, pp. 67-77

Abstract

Heat shock proteins (Hsps), cyclophilins (Cyps) and FK binding proteins (FKBPs) form a family of intracellular chaperone molecules that facilitate protein folding and assembly. These stress proteins are selectively expressedin cells in response to a range of stimuli, including heat, lymphokine andmicrobial/viral infections. This review discusses the role of stress proteins in the HIV-1 viral life cycle, with regard to the development of specific Hsp-based therapeutic strategies against HIV-1 infection. Cumulative findings are cited implicating CypA, Hsp27, Hsp70 and FKBPs in host cell and viral activation, viral entry, assembly or formation of infectious virions. Biological response modifiers that show specific high-affinity interactionswith Cyp, FKBPs and Hsps, including cyclosporins, FK-506 and cyclopentenone prostaglandins respectively, may block HIV-1 replication and infection, providing novel HIV-1 therapeutic strategies. Moreover, Hsp binding to viralcomplexes can enhance antiviral immunity, including natural killer (NK), antibody-dependent (ADCC), gamma delta T-cell and cytotoxic T-lymphocyte (CTL) activities against HIV-1 infected cells. The ability of Hsps to interactwith HIV-1 viral proteins, combined with their inherent adjuvant and immunogenic properties indicates that Hsps may also serve as vehicles for antigen delivery and the design of AIDS vaccines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 19:47:47