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Titolo:
Lentivirus and foamy virus vectors: novel gene therapy tools
Autore:
Pandya, S; Klimatcheva, E; Planelles, V;
Indirizzi:
Univ Rochester, Ctr Canc, Dept Med, Rochester, NY 14642 USA Univ Rochester Rochester NY USA 14642 , Dept Med, Rochester, NY 14642 USA Univ Rochester, Ctr Canc, Dept Microbiol & Immunol, Rochester, NY 14642 USA Univ Rochester Rochester NY USA 14642 & Immunol, Rochester, NY 14642 USA
Titolo Testata:
EXPERT OPINION ON BIOLOGICAL THERAPY
fascicolo: 1, volume: 1, anno: 2001,
pagine: 17 - 40
SICI:
1471-2598(200101)1:1<17:LAFVVN>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; PACKAGING CELL-LINE; MURINE LEUKEMIA-VIRUS; CIS-ACTING SEQUENCES; HEMATOPOIETIC STEM-CELLS; CHEMOKINE RECEPTOR CXCR4; NONDIVIDING HUMAN-CELLS; RETROVIRAL VECTORS; IN-VIVO; EFFICIENT TRANSDUCTION;
Keywords:
design of HIV-1 based vectors; foamy virus based vectors; lentiviral vectors; non-HIV-1 based vectors; safety issues in design of vectors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
181
Recensione:
Indirizzi per estratti:
Indirizzo: Planelles, V Univ Rochester, Ctr Canc, Dept Med, 601 Elmwood Ave, Rochester, NY 14642 USA Univ Rochester 601 Elmwood Ave Rochester NY USA 14642 642 USA
Citazione:
S. Pandya et al., "Lentivirus and foamy virus vectors: novel gene therapy tools", EXPERT OP B, 1(1), 2001, pp. 17-40

Abstract

The aim of gene therapy is to modify the genetic material of living cells to achieve therapeutic benefit. Gene therapy involves the insertion of a functional gene into a cell, to replace an absent or defective gene, or to fight an infectious agent or a tumour. At present, a wide variety of somatic tissues are being explored for the introduction of foreign genes with a view towards treatment. A prime requirement for successful gene therapy is thesustained expression of the therapeutic gene without any adverse effect onthe recipient. A highly desirable vector would be generated at high titres, integrate into target cells (including non-dividing cells) and have little or no associated immune reactions. Lentiviruses have the ability to infect dividing and non-dividing cells and, therefore, constitute ideal candidates for development of vectors for gene therapy. This review presents a description of available lentiviral vectors, including vector design, applications to disease treatment and safety considerations. In addition, general aspects of the biology of lentiviruses with relevance to vector development will be discussed. Recent investigations have revealed that foamy viruses, another group of retroviruses, are also capable of infecting non-dividing cells. Thus, foamy virus vectors are actively being developed in parallel to lentivirus vectors. This review will also include various aspects of the biology of foamy viruses with relevance to vector development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:09:22