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Titolo:
General aspects of anti-angiogenesis and cancer therapy
Autore:
Zogakis, TG; Libutti, SK;
Indirizzi:
NCI, Surg Branch, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, Surg Branch, Bethesda, MD 20892 USA
Titolo Testata:
EXPERT OPINION ON BIOLOGICAL THERAPY
fascicolo: 2, volume: 1, anno: 2001,
pagine: 253 - 275
SICI:
1471-2598(200103)1:2<253:GAOAAC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; MATRIX-METALLOPROTEINASE INHIBITOR; PHASE-II TRIAL; RECOMBINANT HUMAN INTERLEUKIN-12; DOMAIN-CONTAINING RECEPTOR; CALCIUM INFLUX INHIBITOR; CHEMICALLY-MODIFIED TETRACYCLINES; INDEPENDENT PROSTATE-CANCER; METASTATIC BREAST-CANCER; HUMAN COLORECTAL-CANCER;
Keywords:
angiogenesis; cancer therapy; carboxyamido-triazole; endostatin; IL-12; matrix metalloproteinases; suramin; thalidomide; VEGF;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
192
Recensione:
Indirizzi per estratti:
Indirizzo: Libutti, SK NCI, Surg Branch, 10-2B1710 Ctr Dr, Bethesda, MD 20892 USA NCI10-2B1710 Ctr Dr Bethesda MD USA 20892 hesda, MD 20892 USA
Citazione:
T.G. Zogakis e S.K. Libutti, "General aspects of anti-angiogenesis and cancer therapy", EXPERT OP B, 1(2), 2001, pp. 253-275

Abstract

Angiogenesis is the outgrowth of new vessels from pre-existing ones. Tumour growth and metastasis is dependent on angiogenesis and many stimulatory and inhibitory factors have been described which play an active role in thisprocess. Inhibition of tumour neovasculature may be one strategy to inhibit tumour growth. Naturally occurring inhibitors of angiogenesis have been discovered and synthetic agents have been designed. Many of these inhibitorsare currently being evaluated in clinical trials for the treatment of cancer. This review discusses the mechanism of action of these anti-angiogenicsas well as a description of the clinical trials in which they are being evaluated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:49:29