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Titolo:
Potential of anticytokine therapies in central nervous system ischaemia
Autore:
Clark, WM; Lutsep, HL;
Indirizzi:
Oregon Hlth Sci Univ, Dept Neurol UHS44, Oregon Stroke Ctr, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 ke Ctr, Portland, OR 97201 USA
Titolo Testata:
EXPERT OPINION ON BIOLOGICAL THERAPY
fascicolo: 2, volume: 1, anno: 2001,
pagine: 227 - 237
SICI:
1471-2598(200103)1:2<227:POATIC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-1 RECEPTOR ANTAGONIST; TUMOR-NECROSIS-FACTOR; FOCAL CEREBRAL-ISCHEMIA; INTERCELLULAR-ADHESION MOLECULE; FACTOR-ALPHA; BRAIN-DAMAGE; INFLAMMATORY RESPONSE; CEREBROSPINAL-FLUID; MULTIPLE-SCLEROSIS; ICAM-1 EXPRESSION;
Keywords:
central nervous system; cytokines; IL-6; interleukins; stroke;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Clark, WM Oregon Hlth Sci Univ, Dept Neurol UHS44, Oregon Stroke Ctr, 3181SW Sam Jackson Pk Rd, Portland, OR 97201 USA Oregon Hlth Sci Univ 3181 SW Sam Jackson Pk Rd Portland OR USA 97201
Citazione:
W.M. Clark e H.L. Lutsep, "Potential of anticytokine therapies in central nervous system ischaemia", EXPERT OP B, 1(2), 2001, pp. 227-237

Abstract

Central nervous system (CNS) ischaemia is associated with an acute inflammatory response which appears to potentiate CNS injury, especially followingreperfusion. This response includes the release of inflammatory mediators called cytokines including IL-1 and TNF-alpha, which triggers the production of additional cytokines including IL-6 and activates leukocytes which infiltrate into the CNS. Increased expression of cytokines has been demonstrated to occur in the first few hours after CNS ischaemia. Preliminary clinical studies suggest that plasma levels of IL-6 are correlated with functionalrecovery while brain levels of cytokines have been demonstrated to increase following experimental ischaemia. Although there are no current clinical 'anti-cytokine' treatment studies for stroke, experimental studies modulating, IL-1 and TNF-alpha have shown neuroprotection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:00:55