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Titolo:
Optimisation of DNA vaccines for the prophylaxis and modulation of herpes simplex virus infections
Autore:
Eo, SK; Pack, C; Kumaraguru, U; Rouse, BT;
Indirizzi:
Univ Tennessee, Dept Microbiol, Knoxville, TN 37996 USA Univ Tennessee Knoxville TN USA 37996 Microbiol, Knoxville, TN 37996 USA
Titolo Testata:
EXPERT OPINION ON BIOLOGICAL THERAPY
fascicolo: 2, volume: 1, anno: 2001,
pagine: 213 - 225
SICI:
1471-2598(200103)1:2<213:OODVFT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOTOXIC T-LYMPHOCYTES; COLONY-STIMULATING-FACTOR; RECOMBINANT SALMONELLA-TYPHIMURIUM; MEDIATED PROTECTIVE IMMUNITY; ANTIGEN-PRESENTING CELLS; IN-VIVO; PLASMID DNA; DENDRITIC CELLS; BACTERIAL-DNA; COSTIMULATORY MOLECULES;
Keywords:
CpG motifs; DNA vaccines; herpes simplex virus; immunomodulation; mucosal immunity; prime-boost vaccination;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Rouse, BT Univ Tennessee, Dept Microbiol, M409 Walters Life Sci Bldg, Knoxville, TN 37996 USA Univ Tennessee M409 Walters Life Sci Bldg Knoxville TN USA 37996
Citazione:
S.K. Eo et al., "Optimisation of DNA vaccines for the prophylaxis and modulation of herpes simplex virus infections", EXPERT OP B, 1(2), 2001, pp. 213-225

Abstract

Herpes simplex virus (HSV) lacks an effective vaccine. Despite its prevalence and importance HSV infection is not controlled with an acceptable vaccine. Perhaps the best candidate and so far untested approach is the use of plasmid DNA encoding viral proteins. Immunomodulators are also holding some hope as a potential therapeutic. In this review various DNA vaccine approaches used in animal model systems to prevent HSV infections are discussed. judgements are made as to which of these may prove effective for prophylactic or therapeutic vaccines in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 19:37:05