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Titolo:
In utero stem cell transplantation: two steps forward but one step back?
Autore:
Jones, D;
Indirizzi:
Queens Med Ctr, Dept Immunol, Nottingham NG7 2UH, England Queens Med Ctr Nottingham England NG7 2UH l, Nottingham NG7 2UH, England
Titolo Testata:
EXPERT OPINION ON BIOLOGICAL THERAPY
fascicolo: 2, volume: 1, anno: 2001,
pagine: 205 - 212
SICI:
1471-2598(200103)1:2<205:IUSCTT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; FETAL LIVER; GENE-THERAPY; LONG-TERM; PROGENITOR CELLS; MIXED CHIMERISM; TOLERANCE; DIFFERENTIATION; MICROCHIMERISM; STORAGE;
Keywords:
fetal haematopoiesis; in utero transplantation; stem cells; tolerance;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Jones, D Queens Med Ctr, Dept Immunol, Nottingham NG7 2UH, England Queens Med Ctr Nottingham England NG7 2UH gham NG7 2UH, England
Citazione:
D. Jones, "In utero stem cell transplantation: two steps forward but one step back?", EXPERT OP B, 1(2), 2001, pp. 205-212

Abstract

The concept of in utero stem cell transplantation has provided hope that at least some of the genetic disorders which can be diagnosed prenatally canbe treated before the pathological sequelae become manifested. Our increasing knowledge of haematopoietic stem cell biology has provided further possibilities for optimising this transplant procedure. However, the relativelypoor success rate achieved using this procedure has prompted some to suggest that there may be fetal rejection of donor cells via an immune mechanism. However, the prevailing evidence from both animal models and from human cases, suggest that there may be other mechanisms which are preventing successful engraftment in some disorders and these must be addressed if the procedure is to receive further attention. The ability to achieve sustained engraftment after in utero transplantation will have relevance for those seeking to use gene therapy as an alternative therapeutic stratagem.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:22:37