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Titolo:
The clinical potential of novel erythropoiesis stimulating protein
Autore:
Sunder-Plassmann, G; Horl, WH;
Indirizzi:
Univ Vienna, Dept Med 3, Div Nephrol & Dialysis, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 rol & Dialysis, A-1090 Vienna, Austria
Titolo Testata:
EXPERT OPINION ON BIOLOGICAL THERAPY
fascicolo: 4, volume: 1, anno: 2001,
pagine: 733 - 739
SICI:
1471-2598(200107)1:4<733:TCPONE>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-DISEASE; ANEMIA; NEOCYTOLYSIS; TRIAL; DNA;
Keywords:
anaemia of chronic disease; ARANESP; cancer; chemotherapy; darbepoetin alfa; erythropoietin; haemodialysis; NFSP; peritoneal dialysis; pharmacodynamics; pharmacokinetics; renal anaemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Sunder-Plassmann, G Univ Vienna, Innere Med Klin 3, Klin Abt Nephrol & Dialyse, Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18-20 Vienna Austria A-1090
Citazione:
G. Sunder-Plassmann e W.H. Horl, "The clinical potential of novel erythropoiesis stimulating protein", EXPERT OP B, 1(4), 2001, pp. 733-739

Abstract

Novel erythropoiesis stimulating protein (NESP) is a supersialyated analogue of endogenous erythropoietin or recombinant human erythropoietin (rhuEPO). It contains a total of five Winked consensus carbohydrate binding sites in the native protein. NESP has a higher molecular weight due to an increased content of carbohydrates, which, however, has no meaningful influence onthe binding to and activation of the erythropoietin receptor. The major difference in comparison to rhuEPO is the up to threefold increase of the terminal half-life of NESP, which allows for less frequent dosing of NESR Several clinical studies have shown that NESP is as safe and efficient as rhuEPO in correcting renal anaemia and in the maintenance therapy of renal anaemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:54:37