Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Gene therapy for paediatric leukaemia
Autore:
Rousseau, RF; Bollard, CM; Heslop, HE;
Indirizzi:
Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Gene Therapy, Houston, TX 77030 USA
Titolo Testata:
EXPERT OPINION ON BIOLOGICAL THERAPY
fascicolo: 4, volume: 1, anno: 2001,
pagine: 663 - 674
SICI:
1471-2598(200107)1:4<663:GTFPL>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING-FACTOR; BONE-MARROW TRANSPLANTATION; ACUTE LYMPHOBLASTIC-LEUKEMIA; CYTOTOXIC T-LYMPHOCYTES; ACUTE MYELOID-LEUKEMIA; HEMATOPOIETIC STEM-CELLS; AUTOLOGOUS TUMOR-CELLS; ADENOASSOCIATED VIRUS VECTORS; PERIPHERAL-BLOOD LYMPHOCYTES; CHRONIC MYELOGENOUS LEUKEMIA;
Keywords:
adoptive immunotherapy; gene therapy; leukaemia; paediatric leukaemia; vaccines;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
139
Recensione:
Indirizzi per estratti:
Indirizzo: Heslop, HE Baylor Coll Med, Ctr Cell & Gene Therapy, 1102 Bates St,Suite 1140, Houston, TX 77030 USA Baylor Coll Med 1102 Bates St,Suite 1140 HoustonTX USA 77030 A
Citazione:
R.F. Rousseau et al., "Gene therapy for paediatric leukaemia", EXPERT OP B, 1(4), 2001, pp. 663-674

Abstract

Improvements in the chemotherapeutic and transplant regimens have had a significant impact in improving survival rates for paediatric leukaemia. However, there are still important problems to address including what options are available for patients with chemoresistant disease and what strategies are available to avoid the concerns regarding the toxicity associated with highly cytotoxic treatment regimens. Gene therapy and immunotherapy protocols hold great promise. Using gene transfer of a marker gene, a number of biological issues in the therapy of leukaemia have been addressed. For example, by gene marking autologous bone marrow grafts it has been possible to demonstrate that infused marrow contributes to relapse in acute and chronic myeloid leukaemias. In the allogeneic transplant setting, genetically modified T-cells have proven valuable for the prophylaxis and treatment of viral diseases and may have an important role in preventing or treating disease relapse. Gene transfer is also being used to modify tumour function, enhance immunogenicity, and confer drug-resistance to normal haematopoietic stem cells. With the continued scientific advancements in this field, gene therapywill almost certainly have a major impact on the treatment of paediatric leukaemia in the future.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:18:53