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Titolo:
Fighting infection using immunomodulatory agents
Autore:
Masihi, KN;
Indirizzi:
Robert Koch Inst, D-13353 Berlin, Germany Robert Koch Inst Berlin Germany D-13353 ch Inst, D-13353 Berlin, Germany
Titolo Testata:
EXPERT OPINION ON BIOLOGICAL THERAPY
fascicolo: 4, volume: 1, anno: 2001,
pagine: 641 - 653
SICI:
1471-2598(200107)1:4<641:FIUIA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; HERPES-SIMPLEX VIRUS; IMMUNOSTIMULATORY CPG OLIGODEOXYNUCLEOTIDES; BACILLUS-CALMETTE-GUERIN; IMMUNE-RESPONSE MODIFIER; PLACEBO-CONTROLLED TRIAL; THERMALLY INJURED MICE; LONG-TERM PROTECTION; IFN-GAMMA PRODUCTION; CD8(+) T-CELLS;
Keywords:
cytokines; immunomodulators; infections; interleukins;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
112
Recensione:
Indirizzi per estratti:
Indirizzo: Masihi, KN Robert Koch Inst, Nordufer 20, D-13353 Berlin, Germany Robert Koch Inst Nordufer 20 Berlin Germany D-13353 n, Germany
Citazione:
K.N. Masihi, "Fighting infection using immunomodulatory agents", EXPERT OP B, 1(4), 2001, pp. 641-653

Abstract

The last decade has seen the emergence of immunomodulators as promising therapeutic agents in infectious diseases. A diverse array of recombinant, synthetic and natural immunomodulatory preparations for prophylaxis and treatment of various infections are available today. Some of these substances, such as granulocyte colony-stimulating factor (G-CSF), interferons, imiquimod and bacterial-derived preparations are already licensed for use in patients. Others including IL-12, various chemokines, synthetic cytosine phosphate-guanosine (CpG) oligodeoxynucleotides and glucans are being investigated extensively in clinical and preclinical studies. Immunomodulatory regimens offer an attractive approach as an adjunct modality for control of microbial diseases in the era of antibiotic resistance. Practical application of the advances in molecular biology, bioinformatics, genomic mining and high-throughput peptide synthesis should foster future discovery and development of novel immunomodulators contingent upon scientific evidence rather than dictates of discursive empiricism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:31:49