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Titolo:
Genetically engineered antibodies for direct antineoplastic treatment and systematic delivery of various therapeutic agents to cancer cells
Autore:
Bodey, B;
Indirizzi:
Univ So Calif, Sch Med, Dept Pathol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Pathol, Los Angeles, CA 90033 USA Childrens Hosp Los Angeles, Dept Pathol, Div Hematol & Oncol, Los Angeles,CA 90027 USA Childrens Hosp Los Angeles Los Angeles CA USA 90027 Angeles,CA 90027 USA
Titolo Testata:
EXPERT OPINION ON BIOLOGICAL THERAPY
fascicolo: 4, volume: 1, anno: 2001,
pagine: 603 - 617
SICI:
1471-2598(200107)1:4<603:GEAFDA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MONOCLONAL-ANTIBODIES; RICIN-A-CHAIN; GROWTH-FACTOR RECEPTOR; CARCINOEMBRYONIC ANTIGEN ANTIBODIES; CHRONIC LYMPHOCYTIC-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; TUMOR-ASSOCIATED ANTIGENS; HUMAN-MELANOMA CELLS; MALIGNANT-MELANOMA; COLON-CARCINOMA;
Keywords:
anticancer immunotherapy; autocrine stimulation; bispecific antibodies; cancer associated antigens; clinical trials; conjugated mAbs; cytokines; drug-antibody conjugates; genetically engineered (humanised) murine mAbs; growth factors; growth factor receptors; human-human mAbs; IFN-gamma; immunotoxins; mouse antihuman mAb; neoplastic cell specific (antigen directed) chemotherapeutic drug delivery; paracrine stimulation; radionuclide-conjugated mAb;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
179
Recensione:
Indirizzi per estratti:
Indirizzo: Bodey, B Univ So Calif, Sch Med, Dept Pathol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Los Angeles, CA 90033 USA
Citazione:
B. Bodey, "Genetically engineered antibodies for direct antineoplastic treatment and systematic delivery of various therapeutic agents to cancer cells", EXPERT OP B, 1(4), 2001, pp. 603-617

Abstract

Classical antineoplastic therapeutic modalities such as surgery; radiation, and chemotherapy not only fail to cure the great majority of neoplasms, but their employment often leads to severe and debilitating side effects associated with severe neoplasm-related morbidity. Immunotherapy as a fourth modality of anti-cancer therapy has already been proven to be quite effective. The astonishing immunophenotypic (IP) heterogeneity of neoplastic cells,the different cytotoxic activity associated with the moiety linked to given monoclonal antibodies (mAb), and mostly the impressive genetic modulationcapabilities of cancer cells still remain as yet unsolved difficulties in the present immunotherapy of human neoplasms. The advances in mAb production have revitalised the initial concept of use of cancer cell specific "magic bullets. ' Antibodies represent new approaches to anti-cancer therapy: they are neoplastic cell-specific and lethal to neoplastically transformed cells via immune effector mechanisms with no toxicity to normal tissues. They are being observed and developed, adhering to the old prayer: "Destroy the diseased tissues, preserve the normal. " Strategies for the employment of antibodies include: 1) immune reaction directed destruction of neoplastic cells; 2) interference with the growth and differentiation of malignant cells;3) antigen epitope directed transport of anti-cancer agents to neoplastic cells; 4) anti-idiotype tumour vaccines; and 5) development of engineered (humanized) mouse mAbs for anticancer therapy. In addition, a variety of agents (e.g. toxins, radionuclides, chemotherapeutic drugs) have been conjugated to mouse and human mAbs for selective delivery to neoplastic cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:24:30