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Titolo:
Block copolymeric biotransport carriers as versatile vehicles for drug delivery
Autore:
Alakhov, V; Klinski, E; Lemieux, P; Pietrzynski, G; Kabanov, A;
Indirizzi:
Supratek pharma Inc, Laval, PQ H7B 1B7, Canada Supratek pharma Inc Laval PQ Canada H7B 1B7 nc, Laval, PQ H7B 1B7, Canada Univ Nebraska, Med Ctr, Coll Pharm, Dept Pharmaceut Sci, Omaha, NE 68198 USA Univ Nebraska Omaha NE USA 68198 Dept Pharmaceut Sci, Omaha, NE 68198 USA
Titolo Testata:
EXPERT OPINION ON BIOLOGICAL THERAPY
fascicolo: 4, volume: 1, anno: 2001,
pagine: 583 - 602
SICI:
1471-2598(200107)1:4<583:BCBCAV>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CACO-2 CELL MONOLAYERS; SOLUBLE VITAMIN-E; AQUEOUS-SOLUTIONS; MICELLE FORMATION; PLASMID DNA; POLY(ETHYLENE GLYCOL); MULTIDRUG-RESISTANCE; GRAFT-COPOLYMERS; P-GLYCOPROTEIN; INTRAMUSCULAR INJECTION;
Keywords:
biological response modifying agent; block copolymers; combinatorial chemistry; drug delivery; micelles;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
124
Recensione:
Indirizzi per estratti:
Indirizzo: Alakhov, V Supratek pharma Inc, 531 Blvd Prairies,Bldg 18, Laval, PQ H7B 1B7, Canada Supratek pharma Inc 531 Blvd Prairies,Bldg 18 Laval PQ Canada H7B 1B7
Citazione:
V. Alakhov et al., "Block copolymeric biotransport carriers as versatile vehicles for drug delivery", EXPERT OP B, 1(4), 2001, pp. 583-602

Abstract

This review describes block copolymer-based systems that are used in drug formulation development. The use of amphiphilic block copolymers to modify pharmacological performance of various classes of drugs attracts more and more attention. This is largely attributable to the high tendency of block copolymer-based drug formulations to self-assemble, as well as flexibility of block copolymer chemistry, which allows precise tailoring of the carrier to virtually any chemical entity. Combination of these features allows adjustment of block copolymer-based drug formulations to achieve the most beneficial balance in drug biological interactions with the systems that controlits circulation in and removal from the body and its therapeutic activity. The following major aspects are considered: 1) physical properties of formulations and the methods used to adjust these properties towards the highest pharmacological performance of the product; 2) combinatorial methods for optimisation of block copolymer-based formulations; 3) biological response modifying properties of block copolymer-based formulations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:31:11