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Titolo:
Vector-mediated drug delivery to the brain
Autore:
Temsamani, J; Rousselle, C; Rees, AR; Scherrmann, JM;
Indirizzi:
Syntem, F-30000 Nimes, France Syntem Nimes France F-30000Syntem, F-30000 Nimes, France Hop Fernand Widal, INSERM, U26, F-75475 Paris 10, France Hop Fernand Widal Paris France 10 INSERM, U26, F-75475 Paris 10, France
Titolo Testata:
EXPERT OPINION ON BIOLOGICAL THERAPY
fascicolo: 5, volume: 1, anno: 2001,
pagine: 773 - 782
SICI:
1471-2598(200109)1:5<773:VDDTTB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; BARRIER IN-VIVO; RAT-BRAIN; HYPEROSMOLAR SOLUTIONS; STRUCTURAL-CHANGES; TRANSPORT-SYSTEMS; CAROTID INFUSIONS; PEPTIDE; PERMEABILITY; INVIVO;
Keywords:
blood-brain barrier; brain delivery; vector;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Temsamani, J Syntem, Parc Sci Georges Besse, F-30000 Nimes, France Syntem Parc Sci Georges Besse Nimes France F-30000 s, France
Citazione:
J. Temsamani et al., "Vector-mediated drug delivery to the brain", EXPERT OP B, 1(5), 2001, pp. 773-782

Abstract

As a consequence of the growing ageing population, many neurodegenerative diseases, cancer and infections of the brain will become more prevalent. Despite major advances in neuroscience, many potential therapeutic agents aredenied access to the central nervous system (CNS) because of the existenceof the blood-brain barrier (BBB). This barrier is formed by the endothelial cells of the brain capillaries and its primary characteristic is the impermeability of the capillary wall due to the presence of complex tight junctions and a low endocytic activity. The EBB behaves as a continuous lipid bilayer and prevents the passage of polar and lipid-insoluble substances. TheBBB is, therefore, the major obstacle to drugs that are potentially usefulfor combating diseases affecting the CNS. Extensive efforts have been madeto develop CNS drug delivery strategies in order to enhance delivery of therapeutic molecules across the BBB. The current challenge is to develop drug-delivery strategies that will allow the passage of therapeutic drugs through the BBB in a safe and effective manner. This review focuses specifically on the strategies developed to enhance drug delivery across the EBB with an emphasis on the vector-mediated strategy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:03:55