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Titolo:
Bacterial ghosts as carrier and targeting systems
Autore:
Lubitz, W;
Indirizzi:
Univ Vienna, Inst Microbiol & Genet, A-1030 Vienna, Austria Univ Vienna Vienna Austria A-1030 robiol & Genet, A-1030 Vienna, Austria
Titolo Testata:
EXPERT OPINION ON BIOLOGICAL THERAPY
fascicolo: 5, volume: 1, anno: 2001,
pagine: 765 - 771
SICI:
1471-2598(200109)1:5<765:BGACAT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
E-MEDIATED LYSIS; PHI-X174 GENE-E; ESCHERICHIA-COLI; MANNOSE RECEPTOR; PROTEIN-E; CANDIDATE VACCINES; ENDOTHELIAL-CELLS; DENDRITIC CELLS; IN-SITU; MACROPHAGES;
Keywords:
bacterial ghost; carrier and targeting systems; drug delivery; synthetic gene delivery; therapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Lubitz, W Univ Vienna, Inst Microbiol & Genet, Dr Bohrgasse 9, A-1030 Vienna, Austria Univ Vienna Dr Bohrgasse 9 Vienna Austria A-1030 ienna, Austria
Citazione:
W. Lubitz, "Bacterial ghosts as carrier and targeting systems", EXPERT OP B, 1(5), 2001, pp. 765-771

Abstract

Bacterial ghosts are empty cell envelopes originating from Gram-negative bacteria. They have a natural outer surface make-up which provides them withthe original targeting functions of the bacteria they are derived from andare thus able to bind to and/or are taken up by specific cells or tissues of animal, human or plant origin. The extended bacterial ghost system represents a platform technology for creating new qualities in non-living carriers which can be used for the specific targeting of drugs, DNA or other compounds to overcome toxic or non-desired obstacles. Freeze dried bacterial ghosts are stable without the requirement of a cold chain and can be effectively administered orally and aerogenically as drug carriers. The new system is an alternative to liposomes and may have an advantage due to its higher specificity for targeting specific tissues, its easy method of production and its versatility in entrapping and packaging various compounds in different compartments of the carriers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:44:43