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Titolo:
Multiple receptors mediate apoJ-dependent clearance of cellular debris into nonprofessional phagocytes
Autore:
Bartl, MM; Luckenbach, T; Bergner, O; Ullrich, O; Koch-Brandt, C;
Indirizzi:
Univ Mainz, Inst Biochem, D-55099 Mainz, Germany Univ Mainz Mainz Germany D-55099 z, Inst Biochem, D-55099 Mainz, Germany
Titolo Testata:
EXPERIMENTAL CELL RESEARCH
fascicolo: 1, volume: 271, anno: 2001,
pagine: 130 - 141
SICI:
0014-4827(20011115)271:1<130:MRMACO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN RECEPTOR; CLUSTERIN GENE-EXPRESSION; PSEUDOMONAS EXOTOXIN-A; ROD OUTER SEGMENTS; APOLIPOPROTEIN-J; APOPTOTIC CELLS; VITRONECTIN RECEPTOR; GLYCOPROTEIN COMPLEX; AMYLOID-BETA; IN-VITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Koch-Brandt, C Univ Mainz, Inst Biochem, Joachim Becher Weg 30, D-55099 Mainz, Germany Univ Mainz Joachim Becher Weg 30 Mainz Germany D-55099 any
Citazione:
M.M. Bartl et al., "Multiple receptors mediate apoJ-dependent clearance of cellular debris into nonprofessional phagocytes", EXP CELL RE, 271(1), 2001, pp. 130-141

Abstract

Phagocytosis of apoptotic, senescent, and dying cells by macrophages is a well characterized process. More recently it has been shown that in addition to macrophages vital neighboring cells in the affected tissue participatein the cellular clearance. While scavenger receptors have been shown to mediate uptake into macrophages, it is poorly understood how cellular debris is internalized by nonprofessional phagocytes. We here analyze the endocytic activity of vital fibroblasts and epithelial cells exposed to cellular debris and membrane remnants. We show a mutual stimulation in the endocytosisof debris and apolipoproteinJ (clusterin) in these cells. Experiments using RAP (receptor-associated protein) to block ligand binding to LRP and megalin as well as studies in LRP- and megalin-deficient cells suggest that theuptake of apoJ and cellular debris is mediated by megalin, LRP, and yet unidentified internalization mechanisms. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:19:44