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Titolo:
Animal model of diabetic nephropathy
Autore:
Yokozawa, T; Nakagawa, T; Wakaki, K; Koizumi, F;
Indirizzi:
Toyama Med & Pharmaceut Univ, Inst Nat Med, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Toyama Japan 9300194 Toyama 9300194, Japan Toyama Med & Pharmaceut Univ, Fac Med, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Toyama Japan 9300194 Toyama 9300194, Japan
Titolo Testata:
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
fascicolo: 5, volume: 53, anno: 2001,
pagine: 359 - 363
SICI:
0940-2993(200110)53:5<359:AMODN>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-BASEMENT-MEMBRANE; RAT;
Keywords:
diabetic nephropathy; animal model; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Yokozawa, T Toyama Med & Pharmaceut Univ, Inst Nat Med, 2630 Sugitani, Toyama 9300194,Japan Toyama Med & Pharmaceut Univ 2630 Sugitani Toyama Japan 9300194
Citazione:
T. Yokozawa et al., "Animal model of diabetic nephropathy", EXP TOX PAT, 53(5), 2001, pp. 359-363

Abstract

Injection of subtotally nephrectomized rats with streptozotocin produced metabolic abnormalities resembling diabetic nephropathy in humans. These abnormalities were hyperglycemia, hypoinsulinemia, azotemia, hypertriglyceridemia and hypercholesterolemia, accompanied with an increase in glycosylated protein. Extraordinary changes in the urinary excretion of glucose and protein were also observed in rats that received streptozotocin treatment aftersubtotal nephrectomy. In addition, the level of creatinine clearance was significantly decreased. The pathological findings in the kidney of these rats revealed lesions of the glomerular capillary loops, mesangial area and Bowman's capsule. Coagulation was also found in the glomerular capillaries. Our results suggest that this rat model would be useful for studies of diabetic nephropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:34:39