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Titolo:
Assessment of chronic toxicity and carcinogenicity in an accelerated cancer bioassay in rats of moxifloxacin, a quinolone antibiotic
Autore:
Iatropoulos, MJ; Jeffrey, AM; Enzmann, HG; von Keutz, E; Schlueter, G; Williams, GM;
Indirizzi:
New York Med Coll, Dept Pathol, Valhalla, NY 10595 USA New York Med Coll Valhalla NY USA 10595 pt Pathol, Valhalla, NY 10595 USA Bayer AG, D-5600 Wuppertal, Germany Bayer AG Wuppertal Germany D-5600Bayer AG, D-5600 Wuppertal, Germany
Titolo Testata:
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
fascicolo: 5, volume: 53, anno: 2001,
pagine: 345 - 357
SICI:
0940-2993(200110)53:5<345:AOCTAC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIETHYLNITROSAMINE EXPOSURE-RESPONSES; WISTAR RATS; NONLINEARITIES; PROLIFERATION; MECHANISMS;
Keywords:
moxifloxacin; quinolone antibiotic; chronic toxicity; carcinogenicity; accelerated chronic bioassay;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Iatropoulos, MJ New York Med Coll, Dept Pathol, Basic Sci Bldg,Sunshine Cottage Rd, Valhalla, NY 10595 USA New York Med Coll Basic Sci Bldg,Sunshine Cottage Rd Valhalla NY USA 10595
Citazione:
M.J. Iatropoulos et al., "Assessment of chronic toxicity and carcinogenicity in an accelerated cancer bioassay in rats of moxifloxacin, a quinolone antibiotic", EXP TOX PAT, 53(5), 2001, pp. 345-357

Abstract

The chronic toxicity and carcinogenicity of Moxifloxacin (MOX), a bacterial gyrase-inhibiting fluoroquinolone antibiotic, were studied in male and female Wistar rats in an accelerated cancer bioassay (ACB). The ACB is a mechanistic initiation/promotion chronic toxicity and carcinogenicity study designed to assess potential carcinogenic activity of a test substance in critical organs in which human carcinogens are active. The organs studied were liver, lungs, urinary bladder, mammary gland, bone marrow, thymus, spleen and stomach. MOX was given daily by intragastric instillation at 500 mg/kg bw/day for the first 13 weeks to produce potential initiation, followed by promoters (PROs) for 24 weeks, or for the last 24 weeks after 13 weeks of exposure to initiators (INs). The INs, administered during the first 13 weeks, were diethylnitrosamine for the liver, N-n-butyl-N-(4-hydroxybutyl)nitrosamine for the urinary bladder, ethylnitrosourea for the hematolymphoreticular system, N-nitrosodimethylamine for lungs, methylnitrosourea for the stomach and 7,12-dimethylbenz(a)-anthracene for the mammary gland. The PROs, administered during the last 24 weeks after MOX, were phenobarbital for the liver, nitrilotriacetic acid for the urinary bladder, azathioprine for the bone marrow, butylated hydroxytoluene for the lung, butylated hydroxyanisolefor the forestomach, and diethylstilbestrol for the mammary gland. The INsproduced preneoplastic and neoplastic lesions which were not enhanced by MOX, and MOX plus PROs elicited no neoplastic effects, documenting that MOX did not produce either initiation or promotion of neoplasia in any of the target sites, or in any of the other twenty tissues examined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:25:41