Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Infection: friend or foe in the development of atopy and asthma? The epidemiological evidence
Autore:
von Mutius, E;
Indirizzi:
Univ Munich, Dr Von Haunerschen Kinderklin, D-80337 Munich, Germany Univ Munich Munich Germany D-80337 n Kinderklin, D-80337 Munich, Germany
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 5, volume: 18, anno: 2001,
pagine: 872 - 881
SICI:
0903-1936(200111)18:5<872:IFOFIT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY SYNCYTIAL VIRUS; DAY-CARE ATTENDANCE; HAY-FEVER; ALLERGIC SENSITIZATION; MYCOBACTERIUM-TUBERCULOSIS; EAST-GERMANY; BRONCHIAL HYPERRESPONSIVENESS; INTESTINAL MICROFLORA; 8-YEAR-OLD CHILDREN; ENDOTOXIN EXPOSURE;
Keywords:
asthma; atopy; epidemiology; hygiene; infections;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: von Mutius, E Univ Munich, Dr Von Haunerschen Kinderklin, Lindwurmstr 4, D-80337 Munich,Germany Univ Munich Lindwurmstr 4 Munich Germany D-80337 ch,Germany
Citazione:
E. von Mutius, "Infection: friend or foe in the development of atopy and asthma? The epidemiological evidence", EUR RESP J, 18(5), 2001, pp. 872-881

Abstract

There is increasing evidence from epidemiological studies to support tile "hygiene hypothesis" with regard to the development of allergic diseases. This review will discuss the epidemiological findings relating to atopy and asthma, separately. The strongest arguments in favour of the hygiene hypothesis are the findings relating early life day care attendance to a significantly reduced risk of atopy and asthma, and the strong link between sibship size and the occurrence of atopy as confirmed by numerous studies. Furthermore, data relating serological immune responses to certain infections such as hepatitis A and Toxoplasma gondii suggest a role for such infections, or alternatively the lack of hygiene, to be operative in the inhibition of the development of allergic immune responses. The effects described seem to be stronger for atopy than for asthma. Furthermore, biological plausibility for such a hypothesis can be found from findings of recent in vitro studies and from animal experiments. Epidemiological studies attempting to identify single infections as being harmful or beneficial could fail, because it may be the total burden of microbial stimuli rather than a certain infection that directs the maturing immune system into a Th1-type T-helper cell polarized response. The timing of the exposure seems to be essential for promoting beneficial or harmful effects, and may provide a "window of opportunity".

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:31:48