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Titolo:
Association of Gc-globulin variation with susceptibility to COPD and diffuse panbronchiolitis
Autore:
Ishii, T; Keicho, N; Teramoto, S; Azuma, A; Kudoh, S; Fukuchi, Y; Ouchi, Y; Matsuse, T;
Indirizzi:
Yokohama City Univ, Med Ctr, Dept Pulm Med, Minami Ku, Yokohama, Kanagawa 2320024, Japan Yokohama City Univ Yokohama Kanagawa Japan 2320024 anagawa 2320024, Japan Univ Tokyo, Dept Geriatr Med, Tokyo, Japan Univ Tokyo Tokyo JapanUniv Tokyo, Dept Geriatr Med, Tokyo, Japan Int Med Ctr Japan, Res Inst, Dept Resp Dis, Tokyo, Japan Int Med Ctr Japan Tokyo Japan an, Res Inst, Dept Resp Dis, Tokyo, Japan Sanno Hosp, Dept Internal Med, Tokyo, Japan Sanno Hosp Tokyo JapanSanno Hosp, Dept Internal Med, Tokyo, Japan Int Univ Hlth & Welf, Med Res Ctr, Tokyo, Japan Int Univ Hlth & Welf Tokyo Japan Hlth & Welf, Med Res Ctr, Tokyo, Japan Nippon Med Coll, Dept Internal Med 4, Tokyo 113, Japan Nippon Med Coll Tokyo Japan 113 l, Dept Internal Med 4, Tokyo 113, Japan Juntendo Univ, Sch Med, Dept Resp Med, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 , Sch Med, Dept Resp Med, Tokyo 113, Japan
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 5, volume: 18, anno: 2001,
pagine: 753 - 757
SICI:
0903-1936(200111)18:5<753:AOGVWS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; GROUP-SPECIFIC COMPONENT; AIR-FLOW OBSTRUCTION; CHRONIC-BRONCHITIS; GENE POLYMORPHISM; EMPHYSEMA; RISK; CHEMOTAXIS; LUNG;
Keywords:
chronic obstructive pulmonary disease; diffuse panbronchiolitis; Gc-globulin (vitamin D-binding protein); genetic variation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Matsuse, T Yokohama City Univ, Med Ctr, Dept Pulm Med, Minami Ku, 4-57 Urahune Cho, Yokohama, Kanagawa 2320024, Japan Yokohama City Univ 4-57 UrahuneCho Yokohama Kanagawa Japan 2320024
Citazione:
T. Ishii et al., "Association of Gc-globulin variation with susceptibility to COPD and diffuse panbronchiolitis", EUR RESP J, 18(5), 2001, pp. 753-757

Abstract

Chronic obstructive pulmonary disease (COPD) and diffuse panbronchiolitis (DPB) are both characterized by chronic airflow limitation. Although the aetiology of these diseases is under investigation, it is commonly hypothesized that neutrophils a major role in the disease pathogenesis. The variationof the genes related to chemotaxis of neutrophils may confer a risk for the development of both COPD and DPB. In the present report, the authors investigated the association between genetic variation that codes for the 416th and 420th amino acid of Ge-globulin, reported to be associated with chemotaxis of neutrophils, and susceptibility to COPD and DPB. Blood samples obtained front patients with COPD (n=63), DPB (n=82), and control subjects (n=82) were used for the genotyping assay. The proportion of GC*1F homozygotes was significantly higher in the COPD patients than the control subjects (COPD 36.5% versus control 20.7%), and the odds ratio for GC*1F homozygotes was 2.2 (95% confidence interval 1.1-4.6) for the COPD group. There was no difference on the distribution of the other genotypes (GC*1F-1S heterozygotes, GC*1S homozygotes, GC*2-1F heterozygotes, GC*2-1S heterozygotes and GC*2 homozygotes) or the allele frequenciesamong these groups. These findings suggest that the GC*1F gene polymorphism of Gc-globulin maybe one of the risk factors for chronic obstructive pulmonary disease. However, no association between this polymorphism of Ge-globulin and susceptibility to diffuse panbronchiolitis was found.

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Documento generato il 05/04/20 alle ore 19:28:53