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Titolo:
Tissue inhibitor of metalloproteinases-2 gene polymorphisms in chronic obstructive pulmonary disease
Autore:
Hirano, K; Sakamoto, T; Uchida, Y; Morishima, Y; Masuyama, K; Ishii, Y; Nomura, A; Ohtsuka, M; Sekizawa, K;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Pulm Med, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 5, volume: 18, anno: 2001,
pagine: 748 - 752
SICI:
0903-1936(200111)18:5<748:TIOMGP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALVEOLAR MACROPHAGES; EMPHYSEMA; PATHOGENESIS; ANEURYSMS; OXIDANTS; ELASTASE; LUNG;
Keywords:
chronic obstructive pulmonary disease; polymorphism; tissue inhibitors of metalloproteinases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Uchida, Y Univ Tsukuba, Inst Clin Med, Dept Pulm Med, 1-1-1 Tennnoudai, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba 1-1-1 Tennnoudai Tsukuba IbarakiJapan 3058575 apan
Citazione:
K. Hirano et al., "Tissue inhibitor of metalloproteinases-2 gene polymorphisms in chronic obstructive pulmonary disease", EUR RESP J, 18(5), 2001, pp. 748-752

Abstract

Proteinase/antiproteinase imbalance is the most widely accepted theory fordevelopment of chronic obstructive pulmonary disease (COPD). Mutations of tissue of metalloproteinases-2 (TIMP-2) that downregulate its activity may increase the activities of matrix metalloproteinases and result in the degradation of the lung matrix. Polymorphisms of the TIMP-2 gene were investigated in 88 COPD patients and40 control subjects. The variations were examined by single-strand conformational polymorphism analysis followed by sequencing. Two polymorphisms were identified, +853 G/A and -418 G/C nucleotide substitutions. There was a significant deviation in the genotypic frequencies at 853 and the allele frequencies for G were significantly higher in the COPDpatient group than in the control group. For locus -418, the allele frequencies for C in the COPD patient group also tended to be higher than those in the control group. The +853 G/A nucleotide substitution was a silent variant. The -418 G/C substitution was located in the consensus sequence for the Sp1 binding site. These polymorphisms may be associated with the development of chronic obstructive pulmonary disease, decreasing the transcription and stability of the messenger ribonucleic acid, and available as genetic markers of susceptibility to the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:51:31