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Titolo:
Peripheral effects of morphine in neuropathic rats: role of sympathetic postganglionic nerve fibers
Autore:
Pertovaara, A; Wei, H;
Indirizzi:
Univ Turku, Inst Biomed, Dept Physiol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 ept Physiol, FIN-20520 Turku, Finland Univ Helsinki, Inst Biomed, Dept Physiol, Helsinki, Finland Univ HelsinkiHelsinki Finland Biomed, Dept Physiol, Helsinki, Finland
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-3, volume: 429, anno: 2001,
pagine: 139 - 145
SICI:
0014-2999(20011019)429:1-3<139:PEOMIN>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPIOID RECEPTORS; SYSTEMIC MORPHINE; HYPERALGESIA; MONONEUROPATHY; INFLAMMATION; COMPONENT; ANALGESIA; DISORDERS; AFFERENT; LIGATION;
Keywords:
antinociception; morphine; neuropathic pain; sympathectomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Pertovaara, A Univ Turku, Inst Biomed, Dept Physiol, Kiinamyllynkatu 10, FIN-20520 Turku, Finland Univ Turku Kiinamyllynkatu 10 Turku Finland FIN-20520 nland
Citazione:
A. Pertovaara e H. Wei, "Peripheral effects of morphine in neuropathic rats: role of sympathetic postganglionic nerve fibers", EUR J PHARM, 429(1-3), 2001, pp. 139-145

Abstract

We studied the contribution of peripheral opioid receptors to the morphine-induced. antinociception in rats with a spinal nerve ligation-induced neuropathy, Intraplantar (i.pl.) injection of morphine produced a stronger suppression of nociceptive reflex responses of the neuropathic limb following ipsilateral, than contralateral, administration, whereas the morphine-induced effect on the control limb was independent of the injection side. Antinociception induced by systemically administered morphine was significantly attenuated by i.pl. injection of a peripherally acting opioid receptor antagonist in neuropathic but not in sham-operated rats. Following chemical sympathectomy with 6-hydroxydopamine, antinociception was achieved at a lower dose ipsilaterally, than contralaterally, following i.pl. administration of morphine, and the morphine-induced antinociception was attenuated by a peripherally acting opioid receptor antagonist. These results indicate that peripheral opioid receptors may contribute to the morphine-induced antinociception in the spinal nerve ligation-induced model of neuropathy. Sympathectomyof the neuropathic limb may underlie, at least partly, the increased peripheral efficacy of morphine in neuropathy. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 23:17:46