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Titolo:
Melatonin and N-acetylserotonin inhibit leukocyte rolling and adhesion to rat microcirculation
Autore:
Lotufo, CMC; Lopes, C; Dubocovich, ML; Farsky, SHP; Markus, RP;
Indirizzi:
Univ Sao Paulo, Inst Biosci, Dept Physiol, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil Biosci, Dept Physiol, Sao Paulo, Brazil Northwestern Univ, Sch Med, Dept Mol Pharmacol & Biol Chem, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 & Biol Chem, Chicago, IL 60611 USA Northwestern Univ, Sch Med, NW Drug Discovery Program, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 ery Program, Chicago, IL 60611 USA Inst Butantan, Lab Imunoquim, Sao Paulo, Brazil Inst Butantan Sao Paulo Brazil tantan, Lab Imunoquim, Sao Paulo, Brazil
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 430, anno: 2001,
pagine: 351 - 357
SICI:
0014-2999(20011102)430:2-3<351:MANILR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
JUVENILE WISTAR RATS; TAIL ARTERY; RECEPTOR ANTAGONISTS; BINDING-SITES; INFLAMMATION; RESPONSES; STIMULATION; SUBTYPES; VENULES; ZYMOSAN;
Keywords:
inflammation; microcirculation; melatonin; melatonin receptor; N-acetylserotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Markus, RP Univ Sao Paulo, Inst Biosci, Dept Physiol, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil t Physiol, Sao Paulo, Brazil
Citazione:
C.M.C. Lotufo et al., "Melatonin and N-acetylserotonin inhibit leukocyte rolling and adhesion to rat microcirculation", EUR J PHARM, 430(2-3), 2001, pp. 351-357

Abstract

The hormone melatonin produced by the pineal gland during the daily dark phase regulates a variety of biological processes in mammals. The aim of this study was to determine the effect of melatonin and its precursor N-acetylserotonin on the microcirculation during acute inflammation, Arteriolar diameter, blood flow rate, leukocyte rolling and adhesion were measured in therat microcirculation in situ by intravital microscopy. Melatonin alone or together with noradrenaline did not affect the arteriolar diameter or bloodflow rate. Melatonin inhibited both leukocyte rolling and leukotriene B-4 induced adhesion while its precursor N-acetylserotonin inhibits only leukocyte adhesion. The rank order of potency of agonists and antagonist receptorselective ligands suggested that the activation of MT2 and MT3 melatonin binding sites receptors modulate leukocyte rolling and adhesion, respectively. The effect of melatonin and N-acetylserotonin herein described were observed with concentrations in the range of the nocturnal surge, providing thefirst evidence for a possible physiological role of these hormones in acute inflammation. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:00:06