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Titolo:
Involvement of serotonergic and dopaminergic mechanisms in hyperthermia induced by a serotonin-releasing drug, p-chloroamphetamine in mice
Autore:
Sugimoto, Y; Ohkura, M; Inoue, K; Yamada, J;
Indirizzi:
Kobe Pharmaceut Univ, Dept Pharmacol, Higashinada Ku, Kobe, Hyogo 6588558,Japan Kobe Pharmaceut Univ Kobe Hyogo Japan 6588558 , Kobe, Hyogo 6588558,Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 430, anno: 2001,
pagine: 265 - 268
SICI:
0014-2999(20011102)430:2-3<265:IOSADM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT2 RECEPTOR; BRAIN-SEROTONIN; RAT; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; 5-HYDROXYTRYPTAMINE; NEUROTOXICITY; MDMA; THERMOREGULATION; HYPERGLYCEMIA; FENFLURAMINE;
Keywords:
p-chloroamphetamine; hyperthermia; 5-HT (5-hydroxytryptamine, serotonin); dopamine; dopamine D-1 receptor; dopamine D-2 receptor; (mouse);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Sugimoto, Y Kobe Pharmaceut Univ, Dept Pharmacol, Higashinada Ku, Motoyamakita Machi, Kobe, Hyogo 6588558, Japan Kobe Pharmaceut Univ Motoyamakita Machi Kobe Hyogo Japan 6588558
Citazione:
Y. Sugimoto et al., "Involvement of serotonergic and dopaminergic mechanisms in hyperthermia induced by a serotonin-releasing drug, p-chloroamphetamine in mice", EUR J PHARM, 430(2-3), 2001, pp. 265-268

Abstract

Serotonergic and dopaminergic involvement in hyperthermia induced by a serotonin (5-hydroxytryptamine, 5-HT)-releasing drug, p-chloroamphetamine, wasinvestigated in mice. Neither the 5-HT transporter inhibitor fluoxetine nor the 5-HT depleter p-chlorophenylalanine affected p-chloroamphetamine-induced hyperthermia. The dopamine depleter a-methyl-p-tyrosine significantly reduced p-chloroamphenyl-amphetamine-induced hyperthermia. The dopamine D, receptor antagonist 7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SCH 23390) antagonized p-chloroamphetamine-induced hyperthermia, although the dopamine D-2 receptor antagonist sulpiride was withouteffect. These results indicate that p-chloroamphetamine-induced hyperthermia in mice is mediated by dopamine release followed by activation of the dopamine D-1 receptor. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 13:11:11