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Titolo:
Enantioselective synthesis of both enantiomers of various propargylic alcohols by use of two oxidoreductases
Autore:
Schubert, T; Hummel, W; Kula, MR; Muller, M;
Indirizzi:
Forsch Zentrum Julich GmbH, Inst Biotechnol 2, D-52425 Julich, Germany Forsch Zentrum Julich GmbH Julich Germany D-52425 -52425 Julich, Germany Univ Dusseldorf Gelande, Inst Enzymtechnol, Forsch Zentrum Julich GmbH, D-52426 Julich, Germany Univ Dusseldorf Gelande Julich Germany D-52426 , D-52426 Julich, Germany
Titolo Testata:
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
fascicolo: 22, , anno: 2001,
pagine: 4181 - 4187
SICI:
1434-193X(200111):22<4181:ESOBEO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASYMMETRIC REDUCTION; ALPHA,BETA-ACETYLENIC KETONES; THERMOANAEROBACTER-ETHANOLICUS; ALKYNYL KETONES; PSEUDOMONAS SP; DEHYDROGENASE; DERIVATIVES; TEMPERATURE; HYDROLYSIS; CATALYST;
Keywords:
alcohols; alkynones; asymmetric catalysis; oxidoreductases; reductions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, M Forsch Zentrum Julich GmbH, Inst Biotechnol 2, D-52425 Julich, Germany Forsch Zentrum Julich GmbH Julich Germany D-52425 ich, Germany
Citazione:
T. Schubert et al., "Enantioselective synthesis of both enantiomers of various propargylic alcohols by use of two oxidoreductases", EUR J ORG C, (22), 2001, pp. 4181-4187

Abstract

The oxidoreductases Lactobacillus brevis alcohol dehydrogenase (LBADH) andCandida parapsilosis carbonyl reductase (CPCR) are suitable catalysts for the reduction of ketones to afford enantiopure sec. alcohols. A broad variety of alkynones (1, 3, and 5) are accepted as substrates and the corresponding propargylic alcohols (2, 4, and 6) are obtained in good yield and excellent enantiomeric excess. By changing the steric demand of the substituentsthe ee values can be adjusted and even the configurations of the products can be altered.

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Documento generato il 04/04/20 alle ore 20:41:10