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Titolo:
Postnatal increase of procalcitonin in premature newborns is enhanced by chorioamnionitis and neonatal sepsis
Autore:
Janota, J; Stranak, Z; Belohlavkova, S; Mudra, K; Simak, J;
Indirizzi:
Inst Care Mother & Child UPMD, Prague 14700 4, Czech Republic Inst Care Mother & Child UPMD Prague Czech Republic 14700 4 ech Republic Charles Univ, Prague, Czech Republic Charles Univ Prague Czech RepublicCharles Univ, Prague, Czech Republic Cent Mil Hosp, Prague, Czech Republic Cent Mil Hosp Prague Czech Republic nt Mil Hosp, Prague, Czech Republic
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 11, volume: 31, anno: 2001,
pagine: 978 - 983
SICI:
0014-2972(200111)31:11<978:PIOPIP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
INCREASED SERUM PROCALCITONIN; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; EARLY-ONSET SEPSIS; CLINICAL CHORIOAMNIONITIS; EARLY DIAGNOSIS; PLASMA-LEVELS; INFECTION; INFANTS; EXPRESSION;
Keywords:
chorioamnionitis; procalcitonin; sepsis; very low birthweight infant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Janota, J Inst Care Mother & Child UPMD, Podolske Nabrezi 157, Prague 14700 4, CzechRepublic Inst Care Mother & Child UPMD Podolske Nabrezi 157 Prague Czech Republic 14700 4
Citazione:
J. Janota et al., "Postnatal increase of procalcitonin in premature newborns is enhanced by chorioamnionitis and neonatal sepsis", EUR J CL IN, 31(11), 2001, pp. 978-983

Abstract

Background To determine the influence of chorioamnionitis and neonatal sepsis on procalcitonin (PCT) levels in very-low-birth-weight (VLBW) infants within the first week of life. Design PCT serum levels were measured in cord blood 1 h after delivery andon day 3 and day 7 of life. Chorioamnionitis and neonatal sepsis within the first week were monitored. Results Chorioamnionitis was present in eight of 37 patients (21.6%). PCT on day 3 was increased in both the 'No chorioamnionitis' (2.54 ng mL(-1), SEM 0.51) and 'Chorioamnionitis' (6.96 ng mL(-1), SEM 2.93) groups of VLBW infants compared with the 1st hour values (0.45 and 0.58 ng mL(-1) SEM 0.07 and 0.11, respectively, P < 0.001) of the same patients. The postnatal gainwas higher in the 'Chorioamnionitis' group (P < 0.01). Neonatal sepsis wasdiagnosed (after exclusion) in 12 of 32 patients (37.5%). Mean values of maximum PCT in patients with and without sepsis were 8.41 ng mL(-1) (SEM 1.87) and 3.02 ng mL(-1) (SEM 1.38), respectively (P < 0.05). Sensitivity to sepsis of PCT, ratio of immature to total neutrophils (I : T), and C-reactive protein (CRP) were 75%, 50% and 25%, respectively. Conclusions In the group of VLBW infants the PCT level within 72 h of delivery was markedly increased in patients with chorioamnionitis. Compared with I : T and CRP, PCT appears to be a more sensitive marker of neonatal sepsis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:22:58