Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Antiepileptic drugs as independent predictors of plasma total homocysteinelevels
Autore:
Apeland, T; Mansoor, MA; Strandjord, RE;
Indirizzi:
Cent Hosp Rogaland, Dept Internal Med, N-4011 Stavanger, Norway Cent Hosp Rogaland Stavanger Norway N-4011 Med, N-4011 Stavanger, Norway Cent Hosp Rogaland, Dept Clin Chem, N-4011 Stavanger, Norway Cent Hosp Rogaland Stavanger Norway N-4011 hem, N-4011 Stavanger, Norway Cent Hosp Rogaland, Stavanger Neurol Unit, N-4011 Stavanger, Norway Cent Hosp Rogaland Stavanger Norway N-4011 nit, N-4011 Stavanger, Norway
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 1-2, volume: 47, anno: 2001,
pagine: 27 - 35
SICI:
0920-1211(200111)47:1-2<27:ADAIPO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYLENETETRAHYDROFOLATE REDUCTASE GENE; VASCULAR-DISEASE; RISK FACTOR; EPILEPTIC PATIENTS; COMMON MUTATION; HORDALAND HOMOCYSTEINE; ANTICONVULSANT DRUGS; FOLIC-ACID; FOLATE; HYPERHOMOCYSTEINEMIA;
Keywords:
phenytoin; phenobarbital; primidone; valproate; epilepsy; folate; homocysteine; methionine-loading; methylenetetrahydrofolate reductase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Apeland, T Cent Hosp Rogaland, Dept Internal Med, N-4011 Stavanger, NorwayCent Hosp Rogaland Stavanger Norway N-4011 Stavanger, Norway
Citazione:
T. Apeland et al., "Antiepileptic drugs as independent predictors of plasma total homocysteinelevels", EPILEPSY R, 47(1-2), 2001, pp. 27-35

Abstract

Low folate levels have consistently been reported in patients with epilepsy on phenytoin (PHT), phenobarbital (PB) and primidone (PRD), while data onvalproate (VPA) are conflicting. Furthermore. antiepileptic drugs (AEDs) may be associated with high levels of plasma total homocysteine (p-tHcy). Therefore, we have investigated the levels If p-tHcy, serum folate (S-FA) anderythrocyte folate (E-FA) in patients on PHT. PB and PRD (Group 1, n = 21)and VPA (Group 2. n = 24). Both groups had their own matched controls. Blood samples were drawn fasting and 6 h post methionine loading (6 h-PML). The Group 1 patients had fasting and 6 h-PML p-tHcy levels significantly higher than their controls (P = 0.05 and <0.0001, respectively), and patients without dietary multivitamin supplementation (n = 14), had lower fasting S-FA and E-FA levels than their controls (P = 0.02 and 0.0003, respectively). The Group 2 patients had fasting and 6 h-PML levels of p-tHcy, S-FA and E-FA not different from their controls. In a multiple stepwise regression model comprising all subjects (n = 90), the AEDs of Group 1 and the S-FA levelswere independent predictors of p-tHcy levels. Thus, PHT, PB and PRD are associated with high p-tHcy and low folate levels, whereas VPA does not influence S-FA, E-FA and p-tHcy levels in adult patients. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:06:55