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Titolo:
The long-term use of felbamate in children with severe refractory epilepsy
Autore:
Cilio, MR; Kartashov, AI; Vigevano, F;
Indirizzi:
Bambino Gesu Pediat Hosp, Div Neurol, Rome, Italy Bambino Gesu Pediat Hosp Rome Italy ediat Hosp, Div Neurol, Rome, Italy Harvard Univ, Sch Med, Childrens Hosp, Clin Res Core Programs Off, Boston,MA 02115 USA Harvard Univ Boston MA USA 02115 s Core Programs Off, Boston,MA 02115 USA
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 1-2, volume: 47, anno: 2001,
pagine: 1 - 7
SICI:
0920-1211(200111)47:1-2<1:TLUOFI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY RETENTION; CONTROLLED TRIAL; PARTIAL SEIZURES; CARBAMAZEPINE; THERAPY; PHENYTOIN; EFFICACY;
Keywords:
anticonvulsants; felbamate; add-on treatment; intractable seizures; open-label study; long-term follow-up;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Cilio, MR Childrens Hosp, Dept Neurol, EN 316,300 Longwood Ave, Boston, MA02115 USA Childrens Hosp EN 316,300 Longwood Ave Boston MA USA 02115 5 USA
Citazione:
M.R. Cilio et al., "The long-term use of felbamate in children with severe refractory epilepsy", EPILEPSY R, 47(1-2), 2001, pp. 1-7

Abstract

The aim of the study was to assess the efficacy and safety of felbamate (FBM) as add-on therapy in pediatric patients with severe uncontrolled seizures during a 3-year follow-up. Thirty-six patients were enrolled between February 1994 and February 1997. Patients suffered from partial epilepsy (n = 13). Lennox-Gastaut syndrome (LGS) (n = 9). infantile spasms (IS) n = 8 or other forms of generalized epilepsy (n = 6). FBM was titrated weekly from 15 up to 45 mg/kg. By February 1995, all patients had hematological and biochemical monitoring prior to FBM therapy and every 15 days during the study. The results achieved at different treatment durations were analyzed. Overall efficacy measured as greater than or equal to 50% reduction in seizure frequency varied during follow-up: 69% at 3 months, progressively decreasingto 66% at 6 months, to 47% at 1 year and 41% of the initial cohort at the end of the study. Most frequent side effects were anorexia, weight loss, urinary retention, somnolence, nervousness and insomnia. FBM controlled a broad spectrum of otherwise refractory seizures. Best results were obtained against simple partial seizures with or without secondary generalization, tonic and atonic seizures. A substantial improvement in seizure control was maintained in one-third of the patients for at least 3 years. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/05/20 alle ore 15:05:45