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Titolo:
A pharmacoepidemiologic study of factors influencing the outcome of treatment with lamotrigine in chronic epilepsy
Autore:
Wong, ICK; Mawer, GE; Sander, JWAS; Lhatoo, SD;
Indirizzi:
Univ Bradford, Sch Pharm, Pharm Practice Res Unit, Bradford BD7 1DP, W Yorkshire, England Univ Bradford Bradford W Yorkshire England BD7 1DP , W Yorkshire, England Univ Manchester, David Lewis Ctr Epilepsy, Manchester, Lancs, England UnivManchester Manchester Lancs England psy, Manchester, Lancs, England Natl Hosp Neurol & Neurosurg, Inst Neurol, Epilepsy Res Grp, London WC1N 3BG, England Natl Hosp Neurol & Neurosurg London England WC1N 3BG n WC1N 3BG, England
Titolo Testata:
EPILEPSIA
fascicolo: 10, volume: 42, anno: 2001,
pagine: 1354 - 1358
SICI:
0013-9580(200110)42:10<1354:APSOFI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND; ANTIEPILEPTIC DRUGS; MYOCLONIC EPILEPSY; SODIUM VALPROATE; SEIZURES; EFFICACY; RASH;
Keywords:
lamotrigine; chronic epilepsy; pharmacoepidemiology; seizure free; retention rate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Wong, ICK Univ Bradford, Sch Pharm, Pharm Practice Res Unit, Bradford BD7 1DP, W Yorkshire, England Univ Bradford Bradford W Yorkshire England BD7 1DP ire, England
Citazione:
I.C.K. Wong et al., "A pharmacoepidemiologic study of factors influencing the outcome of treatment with lamotrigine in chronic epilepsy", EPILEPSIA, 42(10), 2001, pp. 1354-1358

Abstract

Purpose: To identify prognostic factors for freedom from seizures and long-term retention of treatment in patients receiving lamotrigine (LTG). Methods: A multicenter, retrospective, case record study of 1,050 patientswith chronic epilepsy was carried out. Logistic regression and Cox regression analyses were used to identify clinical features associated with freedom from seizures and retention of treatment, respectively. Long-term retention rates of LTG therapy were estimated using Kaplan-Meier survival analysis. Results: The 1,050 patients with chronic epilepsy were included in the study. Patients with generalized epilepsy (p = 0.01), who were not receiving carbamazepine (CBZ; p = 0.02) were more likely to become seizure-free. Sixtypercent of patients continued on LTG therapy >1 year and estimated retention at 8 years was 38%. Patients with generalized epilepsy (p = 0.002), patients receiving concurrent sodium valproate (VPA; p < 0.0001), those not previously exposed to gabapentin and vigabatrin (p < 0.0001), and those in whom the starting dose was lower (p < 0.0012), were more likely to remain on long-term treatment with LTG. The relationships with exposure to other antiepileptic drugs remained significant in patients with focal and with generalized epilepsy when considered separately. Conclusions: The best results from LTG treatment in terms of freedom from seizures and long-term retention of treatment were obtained in patients with generalized epilepsy. Retention of treatment was enhanced by VPA not onlyin generalized but also in focal epilepsy. The importance of a low starting dose of LTG was again confirmed. The apparent negative effect of CBZ in patients taking LTG merits further investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 08:15:25