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Titolo:
Differential effects of glutamate agonists and D-Aspartate on oxytocin release from hypothalamus and posterior pituitary of male rats
Autore:
Pampillo, M; Diaz, MDC; Duvilanski, BH; Rettori, V; Seilicovich, A; Lasaga, M;
Indirizzi:
Univ Buenos Aires, Fac Med, Ctr Invest Reprod, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1121 Aires, DF, Argentina Consejo Nacl Invest Cient & Tecn, Ctr Estudios Farmacol & Bot, RA-1414 Buenos Aires, DF, Argentina Consejo Nacl Invest Cient & Tecn Buenos Aires DF Argentina RA-1414 entina
Titolo Testata:
ENDOCRINE
fascicolo: 3, volume: 15, anno: 2001,
pagine: 309 - 315
SICI:
1355-008X(200108)15:3<309:DEOGAA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; CENTRAL-NERVOUS-SYSTEM; NEURONS IN-VIVO; SUPRAOPTIC NUCLEUS; VASOPRESSIN NEURONS; RECEPTOR SUBUNITS; ULTRASTRUCTURAL-LOCALIZATION; MAGNOCELLULAR NEURONS; EXPRESSION PATTERNS; NMDA RECEPTORS;
Keywords:
glutamate agonists; oxytocin release; hypothalamus; posterior pituitary;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Lasaga, M Univ Buenos Aires, Fac Med, Ctr Invest Reprod, Paraguay 2155,Piso 10, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Paraguay 2155,Piso 10 Buenos Aires DF Argentina RA-1121
Citazione:
M. Pampillo et al., "Differential effects of glutamate agonists and D-Aspartate on oxytocin release from hypothalamus and posterior pituitary of male rats", ENDOCRINE, 15(3), 2001, pp. 309-315

Abstract

In order to determine whether ionotropic (iGluRs) and metabotropic (mGluRs) glutamate receptor activation modulates oxytocin release in male rats, weinvestigated the effect of agonists of both types of glutamate receptors on oxytocin release from hypothalamus and posterior pituitary. Kainate and quisqualate (1 mM) increased hypothalamic oxytocin release. Their effects were prevented by selective AMPA/kainate receptor antagonists. NMDA (0.01-1 mM) did not modify hypothalamic oxytocin release. Group I mGluR agonists, such as quisqualate and 3-HPG, significantly increased hypothalamic oxytocin release. These effects were blocked by AIDA (a selective antagonist of group I mGluRs). In the posterior pituitary, oxytocin release was not modified by kainate, quisqualate, trans-ACPD (a broad-spectrum mGluR agonist) and L-SOP (a group I I I mGluR agonist). However, NMDA (0.1 mM) significantly decreased oxytocin release from posterior pituitary. D-Aspartate significantlyincreased oxytocin release from the hypothalamus, while it decreased oxytocin release from posterior pituitary. AP-5 (a specific NMDA receptor antagonist) reduced the D-Aspartate effect in the hypothalamus, but not in the posterior pituitary. Our data indicate that the activation of non-NMDA receptors and group I mGluRs stimulates oxytocin release from hypothalamic nuclei, whereas NMDA inhibits oxytocinergic terminals in the posterior pituitary. D-Aspartate also has a dual effect on oxytocin release: stimulatory at thehypothalamus and inhibitory at the posterior pituitary. These results suggest that excitatory amino acids differentially modulate the secretion of oxytocin at the hypothalamic and posterior pituitary levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:43:32