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Titolo:
Effects of thyroid hormone on the renal dopaminergic system
Autore:
Del Compare, JA; Aguirre, JA; Ibarra, FR; Barontini, M; Armando, I;
Indirizzi:
Consejo Nacl Invest Cient & Tecn, Ctr Invest Endocrinol, RA-1425 Buenos Aires, DF, Argentina Consejo Nacl Invest Cient & Tecn Buenos Aires DF Argentina RA-1425 entina
Titolo Testata:
ENDOCRINE
fascicolo: 3, volume: 15, anno: 2001,
pagine: 297 - 303
SICI:
1355-008X(200108)15:3<297:EOTHOT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; URINARY DOPAMINE; ADENOSINE-TRIPHOSPHATASE; SODIUM-EXCRETION; ATPASE ACTIVITY; SENSITIVITY; DYSFUNCTION; NATRIURESIS; INHIBITION; MECHANISMS;
Keywords:
thyroid hormone; renal dopamine; Na+/K+ ATPase; urinary dopamine; 2-thiouracil; dopamine antagonists; SCH-23390; sulpiride; haloperidol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Del Compare, JA Consejo Nacl Invest Cient & Tecn, Ctr Invest Endocrinol, Gallo 1330, RA-1425 Buenos Aires, DF, Argentina Consejo Nacl Invest Cient & Tecn Gallo 1330 Buenos Aires DF Argentina RA-1425
Citazione:
J.A. Del Compare et al., "Effects of thyroid hormone on the renal dopaminergic system", ENDOCRINE, 15(3), 2001, pp. 297-303

Abstract

This study determined the effects of thyroid hormone on the renal dopaminergic system. Surgical thyroidectomy (Tx) and treatment with 2-thiouracil (Thio) decreased renal cortex Na+/K+ ATPase activity an urinary volume. Tx also decreased urinary Na+ and urinary L-DOPA without changing urinary excretion of Dopamine (DA). Thio treatment decreased slightly urinary L-DOPA and Na+, but increased urinary excretion of DA. in both models of thyroid hormone deficiency, the ratio urinary DA/DOPA increased. Changes after Thio treatment were reversed after one month of drug withdrawal. Treatment with T-3 via osmotic minipump increased Na+/K+ ATPase activity and urinary L-DOPA, did not change urinary DA, and increased the ratio DA/DOPA. To further analyze the effects of thyroid hormone deficiency, we administered selective DA(1) (SCH-23390), DA(2) (Sulpiride), and a non selective (Haloperido) DA receptor antagonists to Thio treated and control animals. The DA(1) antagonist decreased diuresis, natriuresis and urinary L-DOPA in control, but had no effect in Thio treated rats. Sulpiride had no effect in either group. The combination of SCH-23390 plus Sulpiride decreased urinary L-DOPA and urinary volume only in Thio treated animals. Haloperidol decreasedurinary volume in Thio treated animals, but had no effect in controls. Our findings suggest that renal DA synthesis is to some extent dependent on thyroid hormone levels, and that the response of DA receptors is altered by thyroid hormone deficiency, indicating a role of is hormone in the regulation of the renal dopaminergic system.

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Documento generato il 29/01/20 alle ore 19:30:04